丙型肝炎患者血清IL-6和IL-12水平与疾病进展的相关性分析  

Correlation between serum IL-6 and IL-12 levels and disease progression in patients with hepatitis C

作　　者：谢梅[1] 王芳[1] XIE Mei;WANG Fang(Department of Infectious Diseases,Yan＇an People＇s Hospital,Yan＇an Shanxi 716000,China)

机构地区：[1]延安市人民医院感染科,陕西延安716000

出　　处：《空军医学杂志》2018年第4期258-261,共4页Medical Journal of Air Force

基　　金：陕西省2015年科学技术研究发展计划项目(2015SF022)

摘　　要：目的探讨丙型肝炎患者血清白介素-6(interleukin-6,IL-6)和白介素-12(interleukin-12,IL-12)水平与肝硬化及癌变的相关性。方法选取延安市人民医院2014年11月—2016年12月收治的丙型肝炎患者47例作为研究对象,根据患者疾病种类,分为慢性丙型肝炎组(22例)、丙肝后肝硬化组(15例)、丙肝相关性肝癌组(10例),另外选取同期同院体检健康者26例作为对照组,比较各组患者肝功能、肝纤维化指标、IL-6和IL-12水平,分析IL-6、IL-12水平与疾病进展的相关性。结果各组患者丙氨酸氨基转移酶(alanine aminotransferase,ALT)、总胆红素(total bilirubin,TBIL)、天冬氨酸转氨酶(aspartate aminotransferase,AST)、碱性磷酸酶(alkaline phosphatase,ALP)、谷氨酰转肽酶(gamma-glutamyl t ranspeptidase,GGT)及总胆汁酸(total bile acid,TBA)水平比较差异有统计学意义(P<0.001);对照组A LT、TBIL、AST、ALP、GGT、TBA水平显著低于慢性丙型肝炎组、丙肝后肝硬化组、丙肝相关性肝癌组(P<0.05);各组患者血清层黏蛋白(laminin,LN)、透明质酸(hyaluronic acid,HA)、Ⅲ型前胶原(typeⅢprocollagen peptide,PCⅢ)及Ⅳ型胶原(typeⅣcollagen,Ⅳ-C)指标水平差异有统计学意义(P<0.001),其中丙肝后肝硬化组LN、HA、PCⅢ及Ⅳ-C水平明显高于对照组、慢性丙型肝炎组、丙肝相关性肝癌组(P<0.05);各组患者血清IL-6、IL-12水平差异有统计学意义(P<0.001);IL-6水平随疾病严重程度而上升(P<0.05);对照组血清IL-12低于慢性丙型肝炎组、丙肝后肝硬化组(P<0.05)。结论丙型肝炎患者血清IL-6及IL-12水平与疾病进展存在一定相关性,IL-6、IL-12水平随疾病严重程度而上升,病程进展至丙肝相关性肝癌时,患者机体IL-12表达水平逐渐下降。ObjectiveTo investigate the relationship between serum interleukin-6（IL-6）and interleukin-12（IL-12）levels in patients with hepatitis C and cirrhosis. MethodsThe patients were divided into chronic hepatitis C group, hepatitis C cirrhosis group and hepatitis C related liver cancer group according to the patient＇s disease type, in addition, 26 healthy people in Yan＇an People＇s Hospital during the same period were selected as control group, compare the liver function, liver fibrosis index, IL-6 and IL-12 levels, and analyze the correlation between IL-6 and IL-12 levels and disease progression. ResultsThere were significant differences in the levels of ALT, TBIL, AST, ALP, GGT and TBA in the patients（P〈0.001）; the levels of ALT, TBIL, AST, ALP, GGT and TBA in the control group were significantly lower than those in the chronic hepatitis C group, hepatitis C cirrhosis group, and hepatitis C related liver cancer group（P〈0.05）; the levels of LN, HA, PC, Ⅲ, Ⅳ and -C in patients of each group were obviously different（P〈0.001）, the levels of LN, HA, PC, PCⅢ, Ⅳ-C in HCV cirrhosis group were higher than those in control group, chronic hepatitis C group and hepatitis C related liver cancer group（P〈0.05）; the serum levels of IL-6 and IL-12 were significantly different in each group（P〈0.001）, the level of IL-6 increased with the severity of the disease（P〈0.05）; the serum IL-12 of the control group wassignificantly less than chronic hepatitis C group, HCV post cirrhosis group（P〈0.05）. Conclusion Serum IL-6 and IL-12 levels are related to disease progression in patients with hepatitis c, the levels of IL-6 and IL-12 increased with the severity of the disease, and the level of IL-12 expression decreased gradually in the course of progression to HCV related hcc.

关 键 词：丙型肝炎 血清IL-6 IL-12 疾病进展 相关性分析 

分 类 号：R512.63[医药卫生—内科学]