侧脑室注射EGb 761对MCAO大鼠神经细胞凋亡的影响  

Effect of Intracerebroventricular Injection of EGb 761 on Neuronal Apoptosis in MCAO Rats

作　　者：孙灵芝[1] 孟苗苗 刘芹 曹晓岚[1] SUN Lingzhi;MENG Miaomiao;LIU Qin;CAO Xiaolan(Department of Encephalopathy,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250011,China;College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250014,China;The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250014,China)

机构地区：[1]山东中医药大学附属医院脑病科,山东济南250011 [2]山东中医药大学中医学院,山东济南250014 [3]山东中医药大学第一临床医学院,山东济南250014

出　　处：《中国中医药现代远程教育》2018年第14期93-96,共4页Chinese Medicine Modern Distance Education of China

基　　金：国家中医药管理局全国名老中医药专家曹晓岚传承工作室项目

摘　　要：缺血性脑卒中缺乏有效的治疗措施,目前应用于临床的许多药物受到血脑屏障的限制,难以充分发挥疗效。EGb761是银杏制剂的提取物,在改善心脑血管疾病方面积累了大量证据。为提高其局部血药浓度,我们采用侧脑室微量泵泵入EGb 761,并观察其对大脑中动脉缺血-再灌注(MCAO)大鼠脑区细胞凋亡的影响,探讨其作用机制及侧脑室注射途径的可行性。There is no effective treatment for ischemic stroke, and many drugs currently used in the clinic are limited by the blood-brain barrier and it is difficult to fully exert its effect. EGb 761 is an extract of Ginkgo biloba, which has accumulated a lot of evidence in improving cardiovascular and cerebrovascular diseases. In order to increase its local plasma concentration, we used a lateral pump to pump EGb 761, and observed its effect on the apoptosis of brain regions in MCAO rats, and explored its mechanism of action and lateral injection pathway feasibility.

关 键 词：EGB 761 缺血性卒中 侧脑室注射 大脑中动脉 缺血-再灌注 即刻基因 c-fos C-JUN 中风 

分 类 号：R285.5[医药卫生—中药学]