地佐辛联合咪达唑仑对硬膜外麻醉手术患者整体临床效果研究  

Overall Analgesic and Sedative Effect and Safety of Dizzozin Combined with Midazolam in Patients Undergoing Epidural Anesthesia

作　　者：钟春元 刘燕萍 李慧伟[1] 何建平[1] ZHONG Chun-yuan;LIU Yan-ping;LI Hui-wei;HE Jian-ping(Department of Pharmacy,Jiangxi Province Xingguo People＇s Hospital,Xingguo Jiangxi 342400,China)

机构地区：[1]江西省兴国县人民医院药剂科,江西兴国342400

出　　处：《药品评价》2018年第16期20-23,共4页Drug Evaluation

摘　　要：目的:研究地佐辛联合咪达唑仑在硬膜外麻醉患者手术中的整体镇痛镇静效果及安全性,为这类手术的开展提供更多麻醉方案。方法:对2012年2月—2014年8月在我院入院治疗的168例硬膜外手术患者进行研究,随机分为两组,每组84例,对照组患者采用地佐辛进行麻醉,观察组患者采用地佐辛联合咪达唑仑进行麻醉。比较麻醉后两组患者内脏牵拉反应情况,两组患者遗忘比例以及两组患者不同时间点VAS疼痛评分比较。比较两组患者麻醉后的镇静程度评分,并比较两组麻醉方案的不良反应发生率。结果:观察组患者内脏牵拉反应II级患者比例明显低于对照组,0级和I级反应比例明显高于对照组,两组间比较差异明显(P<0.05);在遗忘程度比较中,观察组患者完全遗忘及不全遗忘比例明显高于对照组,无遗忘比例明显低于对照组,差异有统计学意义(P<0.05);在两组患者不同时间点VAS评分比较中,观察组在4~24h内的时间点评分显著低于对照组,两组间比较差异有统计学意义(P<0.05);在两组患者镇静程度评分比较中,观察组合格率可达83.9%,远高于对照组62.1%,差异有统计学意义(P<0.05);两组患者不良反应以恶心、头晕、嗜睡和呼吸抑制为主,其中观察组总发生率为14.9%,对照组发生率为29.9%,两组比较差异有统计学意义(P<0.05)。结论:地佐辛联合咪达唑仑用于硬膜外麻醉具有良好的临床效果,患者镇痛、镇静效果优异,内脏牵拉反应更低,遗忘比例更高,且能显著降低单一用药的不良反应,值得推广用。Objective： To study the overall analgesic and sedative effect and safety of dizzozin with midazolam in patients undergoing epidural anesthesia to provide more information on development of these operations. Methods： A total of 168 epidural patients were randomly divided into two groups （n=84）. The patients in the control group were anesthetized with docetaxel and the patients in the observation were performed with dizzozin and midazolam. The visceral traction, the proportion of forgotten, and the VAS pain score at different time points, the sedation score after anesthesia, and the incidence of adverse reaction were compared between the two groups. Results： The proportion of patients with visceral stretch reaction II in the observation group was signi？cantly lower than in the control, and the ratio of the 0 and the 1st grade was signi？cantly higher than the control（P〈0.05）; the rate of complete forgetfulness and total forgetfulness was signi？cantly lower in the observation group than in the control （P〈0.05）. The VAS score of the two groups was signi？cantly lower than the control at 4 h-24h （P〈0.05）; for the sedation score, the pass rate of observation group was 83.9%, which was much higher than control of 62.1% （P〈0.05）; the incidence of nausea, dizziness, drowsiness and respiratory depression in the two groups were 14.9% and 29.9% respectively. There was signi？cant difference between the two groups （P〈0.05）. Conclusion： The effect of dizocine and midazolam for epidural anesthesia was good, the analgesic and sedative effect was excellent, the visceral traction reaction was lower, proportion of forgotten was higher, the adverse reaction was lower, therefore, it is worthy for promoting.

关 键 词：地佐辛 咪达唑仑 硬膜外麻醉 临床观察 

分 类 号：R971.2[医药卫生—药品]