浅层电子线放射治疗背部瘢痕疙瘩的体外实验与临床疗效观察  

Observation the In Vitro Experiment and Clinical Effectof Postoperative Shallow Electron Beam Radiotherapy in the Treatment of Prothorax Keloid

作　　者：王文婷[1] 刘涛[1] 宋海峰[1] 齐予红 曹天宇[1] 张衍国[1] WANG Wen-ting1, LIU Tao1, SONG Hai-feng1, Ql Yu-hong2,CAO Tian-yu1, ZHANG Yan-guo1(1.Department of Dermatology;2.Department of Radiotherapy, Tangdu Hospital, Fourth Military Medical University, Xi＇an 710038, Shaanxi, Chin)

机构地区：[1]第四军医大学唐都医院皮肤科,陕西西安710038 [2]第四军医大学唐都医院放射科,陕西西安710038

出　　处：《中国美容医学》2018年第7期87-90,共4页Chinese Journal of Aesthetic Medicine

基　　金：陕西省科学技术研究发展计划项目(编号:2015SF164)

摘　　要：目的:探讨瘢痕疙瘩成纤维细胞(Keloid Fibroblast,KFs)对不同剂量浅层电子线照射的生物学反应及术后即时浅层电子线放射治疗瘢痕疙瘩的最佳剂量。方法:以人KFs为研究对象,MTT法观察不同剂量浅层电子线照射对KFs增殖的影响,显微镜观察其形态变化。将120例瘢痕疙瘩患者随机分为四组,术后24h内浅层电子线照射剂量分别为2Gy、2.5Gy、3Gy、4Gy,每日照射1次,共照射6次,总剂量为12~24Gy,随访观察其疗效及不良反应。结果:KFs增殖与浅层电子线照射剂量有关,且照射剂量越大,成纤维细胞活力越低;3Gy连续照射6d(总剂量18Gy)对临床瘢痕疙瘩术后疗效最好。结论:术后联合合适剂量的浅层电子线照射治疗是防治瘢痕疙瘩的可靠方法。Objective Exploration the biology reaction of Fibroblast in prothorax keloid with different doses of shallow electron irradiation and the optimum dose for clinical postoperative instant shallow electron radiotherapy dose for KD. Methods Human keloid fibroblasts are selected as the research object and the effect of different doses on the effect of KFs proliferationwas determined by MTT method, and themorphological changes was observed by microscope; 120 KD patients were divided into four groups and the dose of postoperative shallow electron irradiation within 24 h were 2 Gy,2.5 Gy,3 Gy,4 Gy, respectively. One irradiation a day and the total radiation times is 6, the total dose of 12-24 Gy, and the curative effect and adverse reaction is follow-up observed. Results The proliferation inhibition rate of keloid fibroblasts is associated with shallow electron irradiation dose and the fibroblast proliferation inhibition rate is in proportion to irradiation dose; 3 Gy lasting for six days, namely, the 18 Gy total dose has best curative effect for clinical keloids of postoperative shallow electron radiotherapy. Conclusion Postoperative treatment in combination with appropriate dose of shallow electron irradiation is a reliable method in prevention and therapy of keloid.

关 键 词：瘢痕疙瘩 成纤维细胞 浅层电子线照射治疗 剂量 

分 类 号：R619.6[医药卫生—外科学]