基于数据挖掘和网络药理学的痛风湿热蕴结证用药规律和作用机制分析  

Analysis on mechanisms and medication rules of herbal prescriptions for gout caused by heat-damp accumulation syndrome based on data mining and network pharmacology

作　　者：严瑶琦 孙静[1] 张莉[2] 苗丽丽 谢志军[1] YAN Yao-qi;SUN Jing;ZHANG Li;MIAO Li-li;XIE Zhi-jun(Zhejiang Chinese Medical University,Hangzhou 310053,China;Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou 310007,China)

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]杭州市中医院,浙江杭州310007

出　　处：《中国中药杂志》2018年第13期2824-2830,共7页China Journal of Chinese Materia Medica

基　　金：浙江省自然科学基金项目(LQ16H270004)

摘　　要：为了挖掘痛风湿热蕴结证的组方用药规律,并探索核心药物可能的作用机制,收集CNKI中关于痛风湿热蕴结证的相关文献,采用中医传承辅助平台（TCMISSV2.5）分析用药规律,挖掘核心药物配伍和新处方;通过BATMAN-TCM在线分析工具对核心中药配伍进行KEGG通路分析,揭示核心药物配伍治疗痛风湿热蕴结证的潜在信号通路。结果发现,在筛选出的136首处方中,挖掘出6个核心药物配伍和3首新处方。临床治疗痛风湿热蕴结证的核心中药配伍黄柏、牛膝、苍术,其作用的潜在信号通路是嘌呤代谢通路和神经活性配体受体相互作用信号通路。所以,中药治疗痛风湿热蕴结证以清热燥湿、利水消肿、祛风除湿为主,核心药物配伍的作用机制可能是通过干预嘌呤代谢通路和神经活性配体受体相互作用信号通路实现。To mine the medication rules of herbal prescriptions for gout caused by heat-damp accumulation syndrome,and explore the possible mechanism of the core herbs,we collected the relevant literature of gout caused by heat-damp accumulation syndrome in CNKI,medication rules of herbal prescriptions are analyzed by using TCMISS（V2. 5） software,and the compatibility of core drugs and new prescriptions were mined. KEGG pathway analysis was performed by BATMAN-TCM,an online analysis tool,and the potential signaling pathways of core drugs compatibility to treat gout caused by heat-damp accumulation syndrome were revealed. The results showed that six core drugs and three new prescriptions were found out of the 136 prescriptions. The core compatibility herbs in clinical treament of gout caused by heat-damp accumulation syndrome,Phellodendri Chinrnsis Cortex,Achyranthis Bidentatae Radix and Achyranthis Bidentatae Radix,which potential signaling pathways were purine metabolic pathway and neura activity ligand receptor interaction signaling pathway. Therefore,for gout caused by heat-damp accumulation syndrome,the mainly used therapies of TCM were clearing heat and drying dampness,inducing diuresis for removing edema,dispeling wind and eliminating dampness. The mechnisms of core compatibility herbs may be achieved through the intervention of purine metabolic pathway and neural activity ligand receptor interaction signaling pathway.

关 键 词：痛风 湿热蕴结证 数据挖掘 网络药理学 用药规律 作用机制 

分 类 号：R259[医药卫生—中西医结合]