RSV毛细支气管炎患儿血ECP和尿LTE4水平及价值  

Levels and clinical significance of blood eosinophil cationic protein and urinary leukotriene E4 in infants with bronchiolitis

作　　者：党媛媛 严华 冯雪[1] 田庆玲[1] 洪源[1] 杨硕[1] DANG Yuan yuan;YAN Hua;FENG Xue;TIAN Qing-ling;HONG Yuan;YANG Shuo(Department of Infectious Diseases,Tangshan Maternal and Child Health Care Hospital,ttebei Tangshan 063000,China)

机构地区：[1]唐山市妇幼保健院感染性疾病科,河北唐山063000

出　　处：《中国妇幼健康研究》2018年第8期966-969,共4页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨呼吸道合胞病毒(RSV)毛细支气管炎患儿血嗜酸性粒细胞阳离子蛋白(ECP)、尿白三烯E4(LTE4)水平及其临床意义。方法选择2015年3月至2016年3月于唐山市妇幼保健院住院治疗的105例RSV毛细支气管炎患儿为研究对象。通过症状评分将其分为轻度组、中-重度组,以同年龄段的26例健康体检者作为对照组,比较各组间血ECP和尿LTE4水平的差异;分析RSV毛细支气管炎病情评分与血ECP和尿LTE4水平的相关性;应用受试者工作特征(ROC)曲线评估利用血ECP和尿LTE4预测RSV毛细支气管炎后继发哮喘风险的效能。结果中-重度组血ECP和尿LTE4水平显著高于对照组和轻度组(t值分别为11.230、13.068、7.616、7.245,均P<0.05);继发哮喘患儿的血ECP和尿LTE4水平显著高于对照组和无哮喘患儿(t值分别为10.868、11.934、4.538、7.150,均P<0.05)。经线性相关分析显示,RSV毛细支气管炎病情评分与血ECP(r=0.776,P<0.05)和尿LTE4(r=0.765,P<0.05)水平具有明显的相关性。ROC曲线显示,血ECP和尿LTE4单独预测继发哮喘的曲线下面积均低于0.9(AUC分别为0.806和0.855);血ECP和尿LTE4联合预测RSV毛细支气管炎后继发哮喘风险的效能较高(AUC=0.908,P<0.05)。结论 RSV毛细支气管炎患儿血ECP、尿LTE4水平与病情严重程度呈正相关;血ECP联合尿LTE4能够较好地预测患儿继发支气管哮喘的风险。Objective To observe the levels and clinical significance of blood eosinophil cationic protein（ECP）and urinary leukotriene E4（LTE4）in infants with respiratory syncytial virus（RSV）bronchiolitis.Methods Altogether 105 infants with RSV bronchiolitis hospitalized in Tangshan Maternal and Child Health Care Hospital from March 2015 to March 2016 were selected as study subjects.They were divided into mild group and medium-severe group according to symptom scores,and 26 health infants at same age undergoing physical check were taken as control group.Differences in blood ECP and urinary LTE4 levels were compared among groups.Correlation between score of RSV bronchiolitis severity and blood ECP and urinary LTE4 levels was analyzed.Receiver operating characteristic（ROC）curve was plotted to evaluate predict performance of blood ECP and urinary LTE4 for asthma after RSV bronchiolitis.Results Blood ECP and urinary LTE4 levels in medium-severe group were much higher than those in control group and mild group（t value was 11.230,13.068,7.616 and 7.245 respectively,all P〈0.05）.Blood ECP and urinary LTE4 levels in asthma infants were significantly higher than those in control group and non-asthma infants（t value was 10.868,11.934,4.538 and 7.150,respectively,all P〈0.05）.Linear correlation analysis showed that there was an obvious correlation between RSV bronchiolitis severity score and blood ECP（r=0.776,P〈0.05）and urinary LTE4（r=0.765,P〈0.05）.ROC curve revealed that area under curve for prediction of secondary asthma after RSV bronchiolitis by blood ECP or urinary LTE4 alone was less than 0.9（AUC was 0.806 and 0.855 respectively）,but combination of blood ECP and urinary LTE4 had a higher efficiency in prediction for secondary asthma after RSV bronchiolitis（AUC=0.908,P〈0.05）.Conclusion Levels of blood ECP and urinary LTE4 of infants with RSV bronchiolitis are positively correlated with severity of disease.Combination of blood ECP and urinary LTE4 can better predict risk of secondary

关 键 词：呼吸道合胞病毒 毛细支气管炎 嗜酸性粒细胞阳离子蛋白 白三烯E4 

分 类 号：R725[医药卫生—儿科]