面向血管内脂质斑块检测的超声-OCT成像系统  

IVUS-OCT Imaging System for Detection of Intravascular Lipid Plaque

作　　者：徐勇 汪毅[1] 邱建榕 沈毅[2] 肖禹泽 陈晓冬[1] Xu Yong;Wang Yi;Qiu Jianrong;Shen Yi;Xiao Yuze;Chen Xiaodong(Key Laboratory of Optoelectronic Information Technology of the Ministry of Education,School of Precision Instrument and Opto-Electronics Engineering,Tianjin University,Tianjin 300072,Ct;State Key Laboratory of Modern Optical Instrumentation,Institute of Laser Biomedicine,College of Optical Science and Engineering,Zhejiang University,Hangzhou,Zhejiang 310027,China)

机构地区：[1]天津大学精密仪器与光电子工程学院光电信息技术教育部重点实验室,天津300072 [2]浙江大学光电科学与工程学院激光生物医学研究所现代光学仪器国家重点实验室,浙江杭州310027

出　　处：《激光与光电子学进展》2018年第8期380-386,共7页Laser & Optoelectronics Progress

基　　金：国家自然科学基金(61327007);天津市自然科学基金(15JCQNJC14200)

摘　　要：血管内超声(IVUS)和血管内光学相干层析(OCT)成像均属无损医学成像技术,常用于人体冠状动脉中薄纤维帽脂质斑块(TCFA)的检查。其中IVUS的探测深度大,能够较为精确地测定TCFA的脂质核心大小,但由于分辨率较低,无法测量TCFA的纤维帽厚度;而OCT分辨率很高,可以精确测量TCFA的纤维帽厚度,但探测深度浅,无法描述脂质核心的全貌。IVUS与血管内OCT相结合,一次检查即可同时获得血管内壁的超声与OCT图像,实现对血管内血栓与斑块的精准诊断。通过设计IVUS和OCT微型集成探头及近端驱动,实现了一套可同时对血管内壁进行IVUS和OCT成像的系统,对血管组织检测深度达到8mm,横向分辨率优于1mm,轴向分辨率优于400μm,同时在1mm范围内横向分辨率优于10μm,轴向分辨率优于8mm。对琼脂和铁丝等搭建的血管模型样品进行了成像实验,验证了系统的可行性。The intravascular ultrasound（IVUS）and the intravascular optical coherence tomography（OCT）both belong to the non-invasive medical imaging techniques,which are often used for the examination of thin cap fibroatheromas（TCFA）in the human coronary arteries.The detection depth of IVUS is large,so the size of TCFA can be measured accurately,but due to the lower resolution,the fiber cap thickness of TCFA cannot be measured,whereas the OCT has high resolution,which enables it to accurately measure the thickness of the TCFA,but it cannot describe the size of TCFA because of small detection depth.By combining IVUS with OCT,ultrasound and OCT tomographic images of the vascular wall can be obtained simultaneously in a single examination,and the accurate diagnosis of intravascular thrombosis and plaque is achieved.In this paper,we design and realize IVUS and OCT integrated micro-scanning probe and near-end driving module. Meanwhile,a set of system that can simultaneously perform IVUS and OCT imaging on the blood vessel wall is realized.The detection depth of the blood vessel tissue reaches 8 mm,the lateral resolution is better than 1 mm,the axial resolution is better than 400μm,the lateral resolution is better than 10μm and the axial resolution is better than 8μm in the 1 mm range.Vascular models are built with agar and wire,and imaging experiments are performed to verify the feasibility of the system.

关 键 词：医用光学 医学影像诊断 易损斑块 光学相干层析成像 血管内超声成像 

分 类 号：TH773[机械工程—仪器科学与技术]