用于微针经皮给药成像的扫频OCT系统  

Swept Source Optical Coherence Tomography System for Transdermal Drug Delivery Imaging by Microneedles

作　　者：宋思雨[1,2] 李中梁 高云华[2,3] 余俊杰 南楠 王瑄[1,2] 袁春晓[1] 王向朝[1,2] Song Siyu;Li Zhongliang;Gao Yunhua;Yu Junjie;Nan Nan;Wang Xuan;Yuan Chunxiao;Wang Xiangzhao(Laboratory of Information Optics and Optoelectronic Technology,Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences,Shanghai 201800,China;University of Chinese Academy of Sciences,Beijing 100049,China;Key Laboratory of Photochemical Conversion and Optoelectronic Materials,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China)

机构地区：[1]中国科学院上海光学精密机械研究所信息光学与光电技术实验室,上海201800 [2]中国科学院大学,北京100049 [3]中国科学院理化技术研究所光化学转换与功能材料重点实验室,北京100190

出　　处：《中国激光》2018年第8期203-210,共8页Chinese Journal of Lasers

基　　金：上海市科技创新行动计划(15441905600);广西高校光电信息处理重点实验室开放基金(KFJJ2016-04)

摘　　要：微针经皮给药结合了注射和经皮给药两者的优势,可提高大分子药物的经皮吸收量,对皮肤几乎无损害,因此具有良好的应用前景。然而,此技术仍处于发展阶段,需要利用成像手段对微针刺入皮肤的深度、药物颗粒的吸收/释放行为等进行研究。利用圆环达曼光栅产生的贝塞尔光束照射样品,搭建了一套扫频光学相干层析成像(OCT)系统。该系统能够在更长的焦深范围内保持高的横向分辨率,实测系统的有效焦深为1.68 mm,共焦位置附近的横向分辨率为3.61μm,满足微针经皮给药的成像要求。利用搭建的系统对可溶性微针刺入皮肤前后进行成像,能够清晰地看到微针的边缘、刺入深度和在皮肤上留下的微通道,并观察到了微针在皮肤内的溶解过程。Transdermal drug delivery by microneedles combines the advantages of both injection and transdermal drug delivery techniques, greatly enhances the percutaneous absorption of macromolecular drugs with almost no damage to skin, thus has good prospect. However, this technology is still in its infancy, and it is necessary to study the penetration depth of microneedles in the skin and absorption/release behavior of drug particles by means of imaging. A swept source optical coherence tomography system is developed, which uses the Bessel beam, generated by a circular Dammann grating, to illuminate samples. This system exhibits high lateral resolution along an axially extended focal range, the effective depth of focus of the measured system is 1.68 mm and the lateral resolution around the confocal position is 3.61μm, which can meet the imaging requirements for transdermal drug delivery by microneedtes. The proposed system is used to image the dissolving microneedles before and after inserting into the skin, the edge of microneedles, penetration depth and microchannels left on the skin are clearly visible, and the dissolution process of microneedles in skin is observed.

关 键 词：医用光学 扫频光学相干层析成像 微针经皮给药 贝塞尔光束 圆环达曼光栅 

分 类 号：TN247[电子电信—物理电子学]