肥胖2型糖尿病患者腹腔内脂肪面积与微量白蛋白尿的相关性研究  

Correlation between intra-abdominal fat area and microalbuminuria in obese type 2 diabetic patients

作　　者：林毅辉[1] 雷闽湘[2] 蒋建家[1] 黄文森[1] LIN Yihui , LEI Minxiang , JIANG Jianjia , et al.(Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University ,Quanzhou 362000 ,China)

机构地区：[1]福建医科大学附属泉州第一医院内分泌科,泉州362000 [2]中南大学湘雅医院内分泌科

出　　处：《中国糖尿病杂志》2018年第8期640-643,共4页Chinese Journal of Diabetes

摘　　要：目的研究新诊断肥胖T2DM患者腹腔内脂肪面积(VA)与微量白蛋白尿(Umalb)的相关性。方法选取2013年10月至2015年7月于福建医科大学附属泉州第一医院内分泌科就诊的新诊断肥胖T2DM患者192例,根据UACR<30μg/mg,30≤UACR<300μg/mg分为正常白蛋白尿组(n=99)和微量白蛋白尿组(n=93),收集体重、身高、WC、血压、血脂、HbA1c、VA、皮下脂肪面积(SA)等指标,采用稳态模型计算胰岛素抵抗指数(HOMA-IR),比较两组间差异。Logistic回归分析肥胖T2DM患者出现Umalb的影响因素。结果微量白蛋白尿组WC、VA、HOMA-IR、LDL-C、HbA1c高于正常白蛋白尿组(P<0.05)。Logistic回归分析显示,VA、HbA1c、HOMA-IR、LDL-C是肥胖T2DM患者出现Umalb的危险因素(P<0.05)。结论新诊断肥胖T2DM患者Umalb与VA显著相关,与SA无相关性。Objective To investigate the correlation between intra-abdominal fat area and microalbuminuria in newly diagnosed obese type 2 diabetic patients（T2DM）. Methods From October2013 to July 2015,192 newly diagnosed obese T2DM patients from the Department of Endocrinology,Quanzhou first Hospital affiliated to Fujian Medical University,were divided into normal albuminuria group（n=99）and microalbuminuria group（n=93）according to UACR30μg/mg and 30≤UACR300μg/mg.Indexes including body weight,height,waist circumference（WC）,blood pressure,blood lipid,glycosylated hemoglobin（HbA1c）,intra-abdominal fat area（VA）and subcutaneous fat area（SA）were collected and compared.Influence factors of microalbuminuria in obese T2DM patients were evaluated by Logistic regression analysis. Results The levels of WC,VA,HOMA-IR,LDL-C and HbA1 c in microalbuminuria group were significantly higher than those in normal group（P 0.05）.Logistic regression analysis showed that VA,HbA1 c,HOMA-IR and LDL-C were risk factors for microalbuminuria（P〈0.05）. Conclusion Microalbuminuria in newly diagnosed obese T2 DM patients is significantly related to the area of intra-abdominal fat,but not subcutaneous fat.

关 键 词：腹腔内脂肪面积 肥胖 糖尿病 2型 微量白蛋白尿 

分 类 号：R587.1[医药卫生—内分泌]