血清淀粉样蛋白A检测在儿童川崎病诊断中的价值  

Diagnostic value of serum amyliod A in children with Kawasaki disease

作　　者：张丽君 ZHANG Li-jun(The Fourth People＇s Hospital of Liaocheng City,Liaocheng,Shandong,252000,China)

机构地区：[1]聊城市第四人民医院,山东聊城252000

出　　处：《预防医学论坛》2018年第5期390-392,共3页Preventive Medicine Tribune

摘　　要：目的观察血清淀粉样蛋白A(Serum amyliod A,SAA)、C反应蛋白(CRP)在儿童川崎病(Kawasaki disease,KD)中的变化并探讨其诊断价值。方法 2015年2月至2017年12月应用Qpad金标数码分析仪及生化分析仪测定72例川崎病患儿和50名健康儿童血清SAA、CRP的浓度。运用独立样本t检验、Pearson相关分析、χ2检验等统计学方法对数据进行分析。结果 KD组患儿血清SAA、CRP水平显著高于正常对照组(P<0.01);SAA水平与CRP显著正相关(P<0.05);SAA诊断川崎病的效率明显高于CRP(P<0.01)。结果川崎病患儿血清SAA水平显著升高,与急性期炎症密切相关,并且其对于疾病的诊断效率明显高于传统的炎性指标。Objective To observe the changes of serum amyliod A in children with Kawasaki disease（KD）and explore its diagnostic value. Methods A total of 72 children with KD and 50 matched controls were enrolled in the study.The levels of SAA and C-reactive protein（CRP）of all subjects were measured by Qpad gold standard digital analyzer and biochemical analyzer from February 2015 to December 2017.Independent sample t-test,Pearson correlation and chi square test were applied to analyze the data. Results Compared with the controls,children with KD had significantly higher serum levels of SAA and CRP（P〈0.01）.Serum SAA was positively correlated with CRP（P〈0.05）;and the diagnostic efficiency of KD with SAA was significantly higher than that of CRP（P〈0.01）. Conclusion The serum level of SAA in children with KD has been significantly elevated,and it is associated with acute stage inflammation.The positive rate and diagnosis efficiency of KD is significantly higher than that of the traditional inflammatory indicators.

关 键 词：川崎病 血清淀粉样蛋白A 炎性指标 

分 类 号：R58[医药卫生—内分泌]