联合热毒宁注射液、磷酸肌酸钠注射液辅助治疗小儿病毒性心肌炎心电图及血清CK-MB、cTnI水平变化的影响  

Effects of Reduning injection combined with sodium phosphocreatine injection on electrocardiogram and serum CK-MB and cTnI levels in children with viral myocarditis

作　　者：邓松青[1] 梁汉锐 黄增辉 何萍 陈日胜 林玉[1] DENG Song-qing(Pediatric intensive care unit,Maoming maternal and child health care hospital,MaomingGuangdong,525000,China)

机构地区：[1]茂名市妇幼保健院儿童重症监护室,广东525000

出　　处：《齐齐哈尔医学院学报》2018年第7期791-794,共4页Journal of Qiqihar Medical University

摘　　要：目的探讨热毒宁注射液联合磷酸肌酸钠注射液对小儿病毒性心肌炎心电图及血清肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)水平变化的影响。方法选取本院2014年1月—2017年1月收治的139例病毒性心肌炎患儿,按照随机数字表法分为三组,其中对照A组46例,对照B组46例,观察组47例。所有患儿均按"心肌炎"规范治疗。对照A组给予磷酸肌酸钠注射液治疗,对照B组给予热毒宁注射液治疗,观察组给予热毒宁注射液+磷酸肌酸钠注射液治疗,用法用量按药物说明书。观察比较各组临床疗效、心电图变化及血清CK-MB、cTnI水平变化情况,毒副反应发生情况。采用统计学分析方法分析。结果观察组显著改善率为72.34%(34/47),高于对照A组(43.48%)及对照B组(43.48%),差异具有统计学意义(P<0.05);观察组心电图显著改善率为57.45%(27/47),高于对照A组(21.74%)及对照B组(26.09%),差异具有统计学意义(P<0.05);治疗7 d后观察组血清CK-MB、cTnI水平均低于对照组,差异具有统计学意义(P<0.05);观察组血清CK-MB、cTnI恢复时间均小于对照B组及对照A组,差异具有统计学意义(P<0.05);观察组毒副反应发生率为12.77%(6/47),对照A组为8.70%(4/46),对照B组为15.22%(7/46),组间比较差异无统计学意义(P>0.05)。结论联合磷酸肌酸钠注射液、热毒宁注射液治疗病毒性心肌炎,效果显著,可改善患儿心肌酶各指标水平及心电图,促进肌酸激酶同工酶、心肌肌钙蛋白I恢复,且安全性高。Objective To investigate the effects of Reduning injection combined with Sodium phosphocreatine injection on electrocardiogram and serum creatine kinase isoenzyme（ CK-MB） and cardiac troponin I（ c Tn I） in children with viral myocarditis.Methods From January 2014 to January 2017,139 children with viral myocarditis and got treatment in our hospital were selected,they were randomly divided into control group A（ n = 46）,control group B（ n = 46） and observation group（ n = 47）. All patients received standard treatment according to ＂ myocarditis＂. The control group A was treated with Sodium phosphocreatine injection,the control group B was given Reduning injection,and the observation group was treated with Sodium phosphocreatine injection combined with Reduning injection,usage and dosage according to drug instructions. The curative effect,electrocardiogram changes and the serum CK-MB and c Tn I levels were observed and compared of the three groups,and analyzed the occurrence of toxic and side effects using statistical analysis. Results The significant improvement rate in the observation group was 72.34%（ 34/47）,which was higher than that of the control group A（ 43.48%） and the control group B（ 43. 48%）,the difference was statistically significant（ P 0. 05）. The significant improvement rate of ECG was 57.45%（ 27/47） in the observation group,which was higher than that in control group A（ 21.74%） and control group B（ 26.09%）,the difference was statistically significant（ P 0.05）. The CK-MB and c Tn I levels in the observation group were significantly lower than those in the control group A and B after 7 days of treatment（ P 0. 05）. The recovery time of serum CK-MB and c Tn I in the observation group was significantly lower than that in the control groups（ P0.05）. There was no significant difference in the incidence of toxic side effects among the observation group 12.77%（ 6/47） and the control group A 8.70%（ 4/46） and the control group B 6.52%（ 3/46�

关 键 词：病毒性心肌炎 热毒宁注射液 磷酸肌酸钠注射液 心电图 心肌酶谱 

分 类 号：R725[医药卫生—儿科]