α-硫辛酸对2型糖尿病肾病患者血清内脂素的影响研究  

Effect of α-lipoic Acid on Serum Visfatin in Patients with Type 2 Diabetic Nephropathy

作　　者：陆新虹[1] 温玉洁[1] 胡欣[1] 马小燕[2] LU Xin-hong;WEN Yu-jie;HU Xin;MA Xiao-yan(Department of Endocrinology1.Department of Laboratory Medicine;Nanxishan Hospital,Guangxi Zhuang Autonomous Region,Guilin 541002,Guangxi,China)

机构地区：[1]广西壮族自治区南溪山医院内分泌科,广西桂林541002 [2]广西壮族自治区南溪山医院检验科,广西桂林541002

出　　处：《医学信息》2018年第14期60-63,共4页Journal of Medical Information

基　　金：广西卫生厅课题(编号:Z2012231)

摘　　要：目的探讨α-硫辛酸对2型糖尿病患者血清内脂素的影响。方法选取2型糖尿病合并肾病患者90例,按照尿微量白蛋白/肌酐(尿ACR)分为微量蛋白尿硫辛酸治疗组(尿ACR 30~300μg/mg)30例,微量蛋白尿常规治疗组30例,大量蛋白尿硫辛酸治疗组(尿ACR>300μg/mg)30例。常规治疗组给予降糖、降压治疗,硫辛酸治疗组分别在常规治疗基础上给予α-硫辛酸300 mg/d静脉滴注。疗程10 d。治疗前及疗程结束后测定所有参与者尿ACR及血清内脂素。结果微量-常规组治疗后内脂素无改变(35.17±10.64 vs 33.28±9.51 pg/ml,P>0.05),尿ACR无改变(59.5±29.4 vs 60.14±32.51μg/mg,P>0.05);微量-硫辛酸组治疗后内脂素下降(33.31±9.5 vs 28.76±10.79 pg/ml,P<0.01),尿ACR无改变(62.09±35.1 vs 58.29±30.08μg/mg,P>0.05);大量-硫辛酸组治疗后内脂素下降(65.7±17.0 vs 54.62±12.51 pg/ml,P<0.01),尿ACR无改变(459.1±103.5 vs 443.61±109.44μg/mg,P>0.05)。结论α-硫辛酸治疗可以减低糖尿病肾病患者血清内脂素水平,但短疗程(10 d)硫辛酸治疗不能减少尿蛋白排泄率。Objective To investigate the effect of α-lipoic acid on serum visfatin in patients with type 2 diabetes mellitus.Methods90 patients with type 2 diabetes mellitus complicated with nephropathy were enrolled,according to urinary microalbumin/creatinine（urine ACR）,30 cases of microalbuminuria treatment group（urine ACR 30~300μg/mg）,30 cases of microalbuminurial treatment group,and a large number of proteinuria lipoic acid treatment group（ Urinary ACR〉300 μg/mg）in 30 cases.The conventional treatment group was given hypoglycemic and antihypertensive treatment,and the lipoic acid treatment group was given an intravenous infusion of α-lipoic acid 300 mg/d on the basis of conventional treatment.The course of treatment is 10 d.All participants were tested for urinary ACR and serum visfatin before and after treatment.Results There was no change in visfatin after treatment in the micro-routine group（35.17±10.64 vs33.28±9.51 pg/ml,P〉0.05）,and there was no change in urinary ACR（59.5±29.4 vs60.14±32.51μg/mg,P〉0.05）;The visfatin decreased after treatment with the micro-lipoic acid group（33.31 ±9.5 vs28.76±10.79 pg/ml,P〈0.01）,and there was no change in urinary ACR（62.09±35.1 vs 58.29±30.08 μg/mg,P〉0.05）;The visfatin decreased after treatment in the high-lipoic acid group（65.7 ±17.0 vs54.62±12.51 pg/ml,P〈0.01）,and there was no change in urinary ACR（459.1±103.5 vs443.61±109.44 μg/mg,P〉0.05）.Conclusion α-lipoic acid treatment can reduce serum visfatin levels in patients with diabetic nephropathy,but short-course（10 d）lipoic acid treatment can not reduce urinary protein excretion rate.

关 键 词：糖尿病肾病 Α-硫辛酸 内脂素 尿蛋白排泄率 

分 类 号：R587.2[医药卫生—内分泌]