血浆NT-proBNP水平与同型半胱氨酸对糖尿病合并心房颤动的相关性研究  

Correlation between Plasma NT-proBNP level and Homocysteine in Patients with Diabetes Mellitus Complicated with Atrial Fibrillation

作　　者：王淑娟[1] 林祥灿 WANG Shu-juan;LIN Xiang-can(Department of Cardiology,Ocean Petroleum General Hospital,Tianjin 300452,Chin)

机构地区：[1]海洋石油总医院心内科,天津300452

出　　处：《医学信息》2018年第14期169-171,共3页Journal of Medical Information

摘　　要：目的探讨2型糖尿病合并心房颤动患者血N末端B型利钠肽原水平与同型半胱氨酸相关性。方法选取2016年1月~2017年1月在我院接受治疗的T2DM患者120例,根据其有无心房颤动将患者分为房颤组(48例)和无房颤组(72例),所有患者均采用全自动生化分析仪检测血浆NT-proBNP及Hcy的水检测,观察两组血浆NT-proBNP水平与同型半胱氨酸的相关性。结果观察组血浆NT-proBNP、Hcy均高于对照组,差异有统计学意义(P<0.05);观察组血浆NT-proBNP水平与Hcy呈正相关(r=0.328,P<0.05);两组间LAD、LVDD、LVEF、糖尿病病程相比较,差异无统计学意义(P>0.05)。房颤组血浆NTproBNP水平、Hcy高于无房颤组,差异有统计学意义(P<0.05),血浆NT-proBNP水平与Hcy呈正相关(r=0.328,P<0.05)。结论血浆NT-proBNP、Hcy为糖尿病并发房颤的危险因素。可通过联合检测血浆NT-proBNP及Hcy的水平预知糖尿病发生房颤的可能。Objective To investigate the relationship between plasma N-terminal type B natriuretic peptide and homocysteine in patients with type 2 diabetes mellitus complicated with atrial fibrillation.Methods 120 patients with T2 DM who were treated in our hospital from January 2016 to January 2017 were selected.Patients were divided into atrial fibrillation group（n =48）and non-atrial fibrillation group（n=72）according to their presence or absence of atrial fibrillation.The plasma NT-proBNP and Hcy were detected by automatic biochemical analyzer,and the correlation between plasma NT-proBNP and homocysteine was observed. Results The plasma NT-proBNP and Hcy levels in the observation group were significantly higher than those in the control group,the difference was statistically significant（P〈0.05）,the plasma NT-proBNP level in the observation group was positively correlated with Hcy（r=0.328, P〈0.05）,there was no significant difference in the duration of LAD,LVDD,LVEF and diabetes between the two groups（ P 〉0.05）.The plasma NT-proBNP level and Hcy in the atrial fibrillation group were higher than those in the non atrial fibrillation group,the difference was statistically significant（P〈0.05）,and the plasma NT-proBNP level was positively correlated with Hcy（r=0.328,P〈0.05）.Conclusion Plasma NT-proBNP and Hcy are risk factors for diabetes mellitus complicated with atrial fibrillation.The possibility of atrial fibrillation in diabetes can be predicted by combined detection of plasma NT-proBNP and Hcy levels.

关 键 词：糖尿病 心房颤动 血浆NT-PROBNP 同型半胱氨酸 

分 类 号：R587.2[医药卫生—内分泌]