228例HIV感染孕妇分娩新生儿体质量分析  

Analysis on birth weight of 228 neonates born by HIV-infected pregnant women

作　　者：李征[1] 郭晓峰[1] 梁慧超 李晶[1] 李芳[1] 戴卫东[1] LI Zheng;GUO Xiao-Feng;LIANG Hui-Chao(The Eighth People＇s Hospital of Guangzhou,Guangzhou,Guangdong 510060,China)

机构地区：[1]广州市第八人民医院,广东广州510060

出　　处：《中国妇幼保健》2018年第16期3690-3693,共4页Maternal and Child Health Care of China

基　　金：广东省医学科学技术研究基金(B2017034)

摘　　要：目的探讨HIV感染孕妇所分娩新生儿体质量特点,分析HIV感染孕妇分娩小于胎龄儿(SGA)、大于胎龄儿(LGA)的发生率及新生儿体质量与抗病毒治疗的关系。方法选取2009年5月-2015年11月在广州市第八人民医院分娩的HIV感染孕妇为研究对象,采用两种抗逆转录病毒治疗方案治疗,参照广州市不同孕周正常孕妇单胎足月分娩出生体质量标准的研究结果,对所有新生儿体质量进行分析。结果所有研究对象共分娩新生儿228例,其中SGA 31例、占13.60%,LGA 4例、占1.75%。两种治疗方案对新生儿体质量的影响,差异无统计学意义(P>0.05)。在分娩孕周≥38周的新生儿中,仅分娩孕周>39周者,孕28周后与临产后用药的新生儿体质量比较差异有统计学意义(P<0.05)。结论 HIV感染孕妇分娩SGA和低体质量儿的风险增加,孕期抗病毒治疗对新生儿体质量多无明显影响。Objective To explore the characteristics of birth weight of neonates born by HIV-infected pregnant women,analyze the incidence rates of small for gestational age infants（ SGA） and large for gestational age infants（ LGA） born by HIV-infected pregant women,and the relationship between neonatal birth weight and antiviral therapy. Methods From May 2009 to November 2015,HIV-infected pregnant women from the Eighth People＇s Hospital of Guangzhou were selected as study object,then they were treated by two antiretroviral treatment programs. According to the study results of birth weight standard of single full-term delivery in normal pregnant women in different gestational weeks in Guangzhou,birth weights of all the neonates were analyzed. Results A total of 228 neonates were born,the incidence rates of SGA and LGA were 13. 60%（ 31 neonates） and 1. 75%（ 4 neonates）,respectively. There was no statistically significant difference in the effect on neonatal birth weight between the two antiretroviral treatment programs（ P〉0. 05）. Among the neonates with gestational age equal to or more than 38 weeks,there was statistically significant difference in neonatal birth weight between treatment time28 gestational weeks and treatment near the time of labor in neonates with gestational age more than 39 weeks（ P〈0. 05）. Conclusion The risks of SGA and low birth weight infants increase in HIV-infected pregnant women,antiviral therapy during pregnancy has no significant effect on neonatal birth weight.

关 键 词：HIV感染孕妇 小于胎龄儿 低出生体质量儿 抗逆转录病毒治疗 

分 类 号：R173[医药卫生—妇幼卫生保健]