中药复方功效物质基础的研究思路与方法  

Research Ideas and Evaluation of the Functional Material Base of Traditional Chinese Medicine Formula

作　　者：刘建勋[1] 孙明谦[1] 任钧国[1] 林力[1] Liu Jianxun;Sun Mingqian;Ren Junguo;Lin Li(Institute of Basic Medical Sciences of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing Key Laboratory of Pharmacology of Chinese Materia Medica,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院基础医学研究所北京中药药理重点实验室,北京100091

出　　处：《世界科学技术-中医药现代化》2018年第4期473-478,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科技部国家重点基础研究973计划(2015CB554405):基于病证结合的气血相关理论研究;负责人:刘建勋;国家科技部重大专项重大新药创制(2017ZX09301018):病证结合中药复方新药的药效评价关键技术;负责人:任钧国

摘　　要：中药复方的功效代表了复方的整体效应,该效应是中药复方特定化学成分在特定病理条件下对机体发生作用进行调整和整合后的生物效应表达,而这些化学成分就是中药复方功效的物质基础。受多种条件限制,开展中药复方功效物质基础研究的较少,多是药效物质基础的研究,这就造成与中医药理论的脱节,很难对中药复方的功能主治进行科学阐释。在中医药理论和临床实践的指导下,本文提出了中药复方功效物质基础的研究思路与方法进,力争通过多学科、多技术的有机结合,构建中药复方功效物质基础的研究技术体系,进而阐释中药复方功效的产生的化学成分,为中药复方功效物质基础的研究提供借鉴和参考。The function of Traditional Chinese Medicine（TCM） represents the overall effect of the formula. The effect is the expression of numerous biological effects of chemical components of TCM in certain pathological conditions of the body function adjustment, and these chemicals are the material basis of the TCM function. Limited by many conditions,few studies have been done on the material base of TCM function, and most of them have been supplemented by the substance basis of TCM efficacy. This leads to the disconnection between the theory of traditional Chinese medicine and modern research, and it is difficult to scientifically explain the functional indications of Chinese medicine. This paper discusses and summarizes the ideas and methods of modern research and evaluation of the material base of TCM function.Under the guidance of TCM theory and clinical practice, we set up an index system for evaluating the TCM function, and further explained the material basis and action mechanism of TCM formula. Through the organic combination of multidisciplinary and multi-technology, it provides a reference for the establishment of a comprehensive research model of the functional material basis of TCM formula.

关 键 词：中药功效 物质基础 病证结合 作用机理 

分 类 号：R284.3[医药卫生—中药学]