道地药材品质形成机制的组学研究思路  

Thoughts of omics research on quality formation in Dao-di herbs

作　　者：王程成 赵慧[1] 严颖[1] 石婧婧 陈舒妤 谈梦霞 陈佳丽 刘子修[1] 陈翠花 邹立思[1] 刘训红[1] WANG Cheng-cheng;ZHAO Hui;YAN Ying;SHI Jing-jing;CHEN Shu-yu;TAN Meng-xia;CHEN Jia-li;LIU Zi-xiu;CHEN Cui-hua;ZOU Li-si;LIU Xun-hong(School of Pharmacy,Nanjing university of Traditional Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学药学院

出　　处：《中国中药杂志》2018年第11期2407-2412,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81473312);江苏高校优势学科建设工程项目(YSXK-2014);江苏高校品牌专业建设工程项目(PPZY2015A070)

摘　　要：道地药材一直是中药材的＂品质标杆＂,地位不可撼动。道地药材的品质形成从分子层面的基因遗传到最终产物的代谢表型都有涉及,其次生代谢产物的生物合成途径至今并未完全阐明。近年来,不断丰富的组学技术在揭秘复杂生物系统如何运作上功不可没,也同样适用于道地药材复杂的品质形成机制探索。为了缓解道地资源日益匮乏的现状,科学地指导优质品种的移栽,该文综述了组学在解读道地药材从基因到表型的变化过程、次生代谢产物的生物合成途径、与人体的相互作用和品质评价的新方法这些方面的研究成果,为更好地保护和利用中医药资源提供思路。Dao-di herbs have been recognized as ＂ quality models＂ with a firmly stable status. The formation of Dao-di herbs quality is involved from the genetic inheritance on the molecular level to the metabolic phenotype of final products,and the full material-based biosynthetic pathway remains unknown. In recent years,an increasing variety of omics technologies has provided new methods and ideas for the analysis of complex life systems and are suitable for explanation of quality formation in Dao-di herbs as well. In order to alleviate the scarcity of natural resources and offer scientific guidance of transplanting varieties,achievements of omics in the aspects of Dao-di herbs from genetics to phenotyping,the biosynthetic pathway of secondary metabolites,the interaction with human body and the new methods of quality evaluation have been summarized. It will be a fundamental work for protection and utilization of Chinese medicine resources.

关 键 词：道地药材 组学 品质形成 基因遗传 生物合成途径 

分 类 号：S567[农业科学—中草药栽培]