脉络学说指导氧化低密度脂蛋白致动脉粥样硬化病理机制探讨  

Pathological Mechanism of Atherosclerosis Induced By Oxidized Low Density Lipoprotein Guided By The Channel-Collateral Theory

作　　者：李红蓉[1,2] 秘红英 赵齐飞 任红 LI Hong-rong;MI Hong-ying;ZHAO Qi-fei;REN hong(Graduate School of Hebei Medical University,Shifiazhuang 050017,China;Key Laboratory of State Administration of TCM（Cardio-Cerebral Vessel Collateral Disease）,Shifiazhuang 050035,China;Key Laboratory of Hebei Province for Collateral Diseases,Shijiazhuang 050035,China;Key Disciplines of State Administration of TCM for Collateral Disease,Shifiazhuang 050035,China)

机构地区：[1]河北医科大学研究生学院,石家庄050017 [2]国家中医药管理局重点研究室(心脑血管络病),石家庄050035 [3]河北省络病重点实验室,石家庄050035 [4]国家中医药管理局中医络病学重点学科,石家庄050035

出　　处：《中国中医基础医学杂志》2018年第7期945-948,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家重点基础研究发展计划(973计划)(2012CB518606)

摘　　要：氧化低密度脂蛋白是动脉粥样硬化的重要危险因素,可以从多方面损伤血管内皮并进一步参与动脉粥样硬化的发生发展。血液中的氧化低密度脂蛋白属于中医"脂浊"范畴,可以导致胸痹心痛、心悸、心水、中风等脉络病变。脉络学说主张从络气角度研究"脉络—血管系统病"的发病机制,对"脉络—血管系统病"的防治具有重要指导价值。以脉络学说为指导,氧化低密度脂蛋白诱发动脉粥样硬化的病理过程是由络气郁滞/虚滞发展到脉络瘀阻的过程。Oxidized low density lipoprotein（LDL） is an important risk factor for atherosclerosis,which can damage endothelial cells in many ways and further cause atherosclerosis. Oxidized low density lipoprotein has been considered to be part of ＂lipid turbidity ＂ category in Chinese medicine,which is a major cause of vessel collateral diseases,such as obstruction of heartache,palpitation,heart water and stroke. Vessels Collateral Theory study the pathogenesis of vesselvascular system diseases in perspective of collateral-qi,which is of important theoretical meaning for the improvement of diagnosis and treatment level of vessel-vascular system diseases. Under the guidance of Vessels Collateral Theory,the pathological process of atherosclerosis induced by oxidized low density lipoprotein is a progression form collateral-qi deficiency and stagnation to stasis obstruction of the collateral.

关 键 词：动脉粥样硬化 脉络—血管系统病 氧化低密度脂蛋白 络气郁滞/虚滞 脉络瘀阻 

分 类 号：R541.4[医药卫生—心血管疾病]