透明质酸钠注射液联合塞来昔布治疗膝骨关节炎的临床疗效及其对患者炎性因子的影响  

Clinical effect of sodium hyaluronate injection combined with celecoxib in treating knee osteoarthritis and the impact on inflammatory factors of patients

作　　者：巫海鹏 陈守勃[1] 施劲楠 林欣欣[2] WU Hai-peng;CHEN Shou-bo;SHI Jin-nan(Department of Orthopedics,Second Affiliated Hospital of Fujian Medical University,Quanzhou362000,Chin)

机构地区：[1]福建医科大学附属第二医院骨科,福建省泉州市362000 [2]福建医科大学附属第二医院风湿免疫科,福建省泉州市362000

出　　处：《临床合理用药杂志》2018年第21期25-27,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨透明质酸钠注射液联合塞来昔布治疗膝骨关节炎(KOA)的临床疗效及其对患者炎性因子的影响。方法选取福建医科大学附属第二医院2016年1月—2017年1月收治的KOA患者88例,按照随机数字表法分为对照组44例与观察组44例。对照组予以塞来昔布口服治疗,观察组在对照组基础上给予透明质酸钠注射液治疗,两组患者均持续治疗5周。随访12周,比较两组患者治疗前后静息疼痛积分、活动疼痛积分、关节压痛积分、关节肿胀积分,治疗前后炎性因子[C-反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)]水平,近期疗效、远期疗效,并观察患者不良反应发生情况。结果治疗前,两组患者静息疼痛、活动疼痛、关节压痛、关节肿胀积分比较,差异无统计学意义(P>0.05);治疗后,观察组患者静息疼痛、活动疼痛、关节压痛、关节肿胀积分低于对照组(P<0.05)。治疗前,两组患者CRP、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者CRP、TNF-α水平低于对照组(P<0.05)。观察组近期疗效、远期疗效均优于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论透明质酸钠注射液联合塞来昔布治疗KOA的临床疗效确切,可有效缓解患者的临床症状,减轻炎性反应。Objective To discuss the clinical effect of sodium hyaluronate injection combined with celecoxib in treating knee osteoarthritis（KOA） and the impact on inflammatory factors of patients.Methods A total of 88 cases of KOA patients were selected from January 2016 to January 2017 in the Second Affiliated Hospital of Fujian Medical University,which were divided into control group and observation group according to random number table,44 cases in each group.The control group was treated with celecoxib,observation group was treated with sodium hyaluronate injection based on control group,both groups were treated for 5 weeks.Followed-up 12 weeks,the scores of resting pain,activity pain,articular pain,arthrocele,inflammatory factors（CRP,TNF-α） before and after treatment,short-term effect,long-term effect were compared between the two groups,and the incidence of adverse reactions were observed.Results Before treatment,no significant differences of the scores of resting pain,activity pain,articular pain or arthrocele was found between the two groups（P〈0.05）;after treatment,the scores of resting pain,activity pain,articular pain,arthrocele in observation group were lower than control group（P〈0.05）.Before treatment,no significant differences of CRP or TNF-α was found between the two groups（P〈0.05）;after treatment,the CRP,TNF-α levels in observation group were lower than control group（P〈0.05）.The observation group of short-term effect,long-term effect were better than control group（P〈0.05）.There was no significant difference in incidence rate of adverse reactions between the two groups（P〈0.05）.Conclusion Sodium hyaluronate injection combined with celecoxib have an exactly clinical effect in treating KOA,it can effectively improve the clinical symptoms of patients,reduce inflammatory response.

关 键 词：骨关节炎 膝 透明质酸钠 塞来昔布 炎性因子 治疗结果 

分 类 号：R684.3[医药卫生—骨科学]