中西医结合治疗慢性肾衰竭的效果及对血清FN、PAI-1水平变化的影响  

Effect of Traditional Chinese and Western Medicine on Serum Levels of FN and PAI-1 in Patients with CRF

作　　者：杜冬琛 DU Dongchen(Department of Nephropathy,Yichang Hospital of TCM Hubei,Yichang 443000,Hubei,Chin)

机构地区：[1]宜昌市中医医院肾病科

出　　处：《中华中医药学刊》2018年第8期2005-2007,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：宜昌市科学研究与开发项目医疗卫生项目(A13301-47)

摘　　要：目的：分析中西医结合疗法对慢性肾衰竭（CRF）患者疗效及对血清纤维连接蛋白（FN）、纤溶酶原激活物抑制剂-1（PAI-1）水平变化影响。方法：回顾性选取2015年4月-2017年2月医院收治的CRF患者79例，根据用药不同分为对照组和观察组。对照组患者给予肾衰一体化治疗，观察组患者在肾衰一体化治疗基础上联合中药汤剂补脾益肾活血降浊方加减治疗。观察两组患者治疗前后中医证候积分、营养评分、炎症因子、肾脏血流动力学指标、肾功能指标、FN及PAI-1水平变化情况。结果：两组患者治疗后中医证候积分及营养评分均较治疗前改善，观察组患者治疗后中医证候积分及营养评分均优于对照组（P〈0．05）。两组患者治疗后IL-6、ICAM-1及MCP-1水平均较治疗前下降，观察组患者治疗后IL-6、ICAM-1、MCP-1、Scr、BUN、FN及PAI-1水平均低于对照组（P〈0．05）。两组患者治疗后肾动脉内径和肾动脉阻力指数水平均较治疗前改善，观察组患者治疗后肾动脉内径和肾动脉阻力指数水平水平均优于对照组（P〈0．05）。结论：中西医结合疗法治疗慢性肾衰竭可减轻患者临床症状，降低患者ICAM-1、MCP-1、FN及PAI-1水平，改善机体营养状况和肾脏血流动力学水平。Objective ： To analyze the curative effect of integrated traditional Chinese and Western medicine on the pa- tients with chronic renal failure（CRF） and the influence on serum fibronectin（FN） and plasminogen activator inhibitor - 1 （PAI - 1 ） levels. Methods ： From April 2015 to February 2017 in our hospital,？9 cases of patients with CRF, according to the medication were divided into control group and observation group. The patients in the control group were given inte- grated treatment of renal failure, and the observation group was treated with the combination of tonifying spleen, tonifying kidney, promoting blood circulation and reducing turbidity, based on the integrative treatment of renal failure. We ob- served two groups＇ syndrome integral, nutrition score, inflammatory factor, renal hemodynamics, renal function, changes of FN and PAI- 1 level before and after treatment. Results ： The scores of TCM syndromes and nutrition scores of the two groups were better than those before treatment. The scores of TCM syndromes and nutritional scores in the observation group after treatment were better than those in the control group（ P 〈 O. 05 ）. After treatment, the levels of IL -6, ICAM - 1 and MCP - 1 in the two groups were lower than those before treatment, and the levels of IL -6, ICAM - 1, MCP - 1, Scr, BUN, FN and PAI- 1 in the observation group were lower than those in the control group （P 〈0. 05）. The di- ameter of the renal artery and the index of renal artery resistance were improved in the two groups after treatment, and the diameter of the renal artery and the level of the renal artery resistance index in the observation group were better than those in the control group（P 〈0.05 ）. Conclusion：Treatment of chronic renal failure with combination of traditional Chi- nese and Western medicine can alleviate the clinical symptoms, reduce the levels of ICAM - 1, MCP - 1, FN and PAI - 1 and improve the nutritional status and renal hemodynamics in patients with chronic renal

关 键 词：中西医结合 慢性肾衰竭 血清纤维连接蛋白 肾脏血流动力学 

分 类 号：R692.5[医药卫生—泌尿科学]