心血管疾病患者血栓前状态相关指标检测  

Study on risk factors of prethrombotic state in patients with cardiovascular disease

作　　者：韩崇旭[1] 韩月玲[2] 李锦堂[1] 黄振文[3] 刘瑞云[3] 

机构地区：[1]郑州大学第一附属医院检验科,郑州450052 [2]郑州大学第一附属医院急诊科,郑州450052 [3]郑州大学第一附属医院心内科,郑州450052

出　　处：《郑州大学学报（医学版）》2002年第5期585-588,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省重大科技攻关项目9712 0 0 10 0 0

摘　　要：目的 :探讨血栓前状态 (prethromboticstate ,PTS)相关指标与心血管疾病的关系。 方法 :检测 66例急性心肌梗死 (血栓形成组 ) ,54例心绞痛 (血栓前状态组 )和 30例健康对照者 (对照组 )的血小板P 选择素 (P selectin)、血栓素B2 (TXB2 )、6 酮 前列腺素F1α(6 K PGF1α)、血管性假血友病因子 (vWF)、抗凝血酶 (AT)、组织纤溶酶原激活物抑制物活性 (PAI 1活性 )、D 二聚体 (D dimer)、一氧化氮 (NO)、组织纤溶酶原激活物含量 (t PA含量 )及组织纤溶酶原激活物活性 (t PA活性 )。结果 :与对照组比较 ,血栓前状态组的P selectin、TXB2 、PAI 1活性均显著升高(P <0 .0 5～ 0 .0 0 1 ) ,AT、t PA活性均显著降低 (P <0 .0 5～ 0 .0 0 1 ) ;血栓形成组的P selectin、TXB2 、vWF、PAI 1活性、D dimer、NO、t PA含量均显著升高 (P <0 .0 1～ 0 .0 0 1 ) ,6 K PGF1α、AT、t PA活性均显著降低 (P <0 .0 5～ 0 .0 0 1 )。血栓形成组与血栓前状态组相比 ,血栓形成组的TXB2 、vWF、PAI 1活性、D dimer、NO、t PA含量均显著升高 (P <0 .0 5～ 0 .0 0 1 ) ,6 K PGF1α、AT、t PA活性均显著降低 (P <0 .0 5～ 0 .0 1 )。多元Logistic回归发现 ,TXB2 、P selectin、PAI 1活性、t PA活性变化与PTS最为密切。结论 :TXB2 ?Aim: To study the risk factors of prethrombotic state(PTS) in patients with cardiovascullar disease. Methods: Platelet P selectin,thromboxane B 2 (TXB 2), 6 keto prostaglandin F1α (6 K PGF1α), von willebrand factor( vWF), antithrombin (AT), plasminogen activator inhibitor activity(PAI:a), D dimer, nitric oxide(NO), tissue plasminogen activator activity (t PA:a), and tissue plasminogen activator antigen(t PA: Ag)in plasma were measured in 120 patients with acute myocardial infarction (thrombosis group, n =66), angina pectoris (prethrombotic state group,PTS group, n =54) and in 30 healthy persons(control group). Results: Compared with the control group, the average values of P selectin, TXB 2, PAI 1:a in the PTS group were significantly increased ( P <0.05～0.001),while the average values of AT and t PA:a were markedly decreased( P <0.05～0.001). The average values of P selectin, TXB 2, vWF, PAI 1:a, D dimer, NO, and t PA:Ag in the thrombosis group were significantly increased ( P <0.01～0.001),while the average values of 6 K PGF1α, AT, and t PA:a were markedly decreased( P <0.05～0.001). Compared with the PTS group, the average values of TXB 2, vWF, PAI 1:a, D dimer, NO, and t PA:Ag in the thrombosis group were significantly increased ( P <0.05～0.001),while the average values of 6 K PGF1α, AT, and t PA:a were markedly decreased( P <0.05～0.01). The logistic regression analysis showed that the TXB 2, P selectin, PAI 1:a, and t PA:a were closely related to the values of PTS. Conclusions: The high activity of TXB 2, P selectin, PAI 1:a, and t PA:a may play an important role in PTS.

关 键 词：血栓前状态 心肌梗死 心绞痛 血栓前状态 血小板P-选择素 血栓素B2 组织纤溶酶原激活物抑制物活性 PTS 

分 类 号：R54[医药卫生—心血管疾病]