早搏宁冲剂的抗实验性心律失常作用  

Effects of Zaoboning Chongji on experimental arrhythmia

作　　者：刘红[1] 戚敏[1] 胡香杰[1] 张贵卿[1] 

机构地区：[1]郑州大学基础医学院药理教研室,郑州450052

出　　处：《郑州大学学报（医学版）》2002年第5期650-652,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的 :观察早搏宁冲剂对实验性心律失常的影响。方法 :采用Wistar大鼠、豚鼠、家兔 ,观察早搏宁冲剂对乌头碱诱发大鼠心律失常和哇巴因诱发豚鼠心律失常的影响 ,以及早搏宁冲剂对电刺激家兔室颤阈及结扎大鼠冠状动脉诱发心律失常的影响。结果 :早搏宁冲剂可增加乌头碱及哇巴因诱发心律失常的用量 ,提高电刺激家兔室颤阈值 ,延迟结扎大鼠冠状动脉心律失常出现时间 ,减少早搏次数及室速持续时间。结论 :早搏宁冲剂具有抗实验性心律失常作用 。Aim: To observe the effects of Zaoboning Chongji on experimental arrhythmia. Methods:Zaoboning Chongji was given to 3 groups (Wistar rats,guinea pigs,and rabbits).Acconitine,ouabain,and electric stimulation were respectively used with 3 groups to induce arrhythemia.Results: Zaoboning Chongji increased the threshold and the doses of acconitine or ouabain which was used for inducing arrhythmia. The times of premature systoles and duration of ventricular tachyarrhythmia were reduced. Conclusion: Zaoboning Chongji has anti arrhythmic effects in dose dependent manner.

关 键 词：早搏宁冲剂 抗心律失常 乌头碱 哇巴因 室颤阈 

分 类 号：R285.5[医药卫生—中药学] R259.4[医药卫生—中医学]