长期有氧运动对老年大鼠骨组织维生素D受体表达的影响  

Effects of Chronic Aerobic Exercise Training on Expression of Vitamin D Receptor in Bone Tissues of Aged Rats

作　　者：王兵[1] 侯俊[2] WANG Bing;HOU Jun(School of Physical Education,Xi＇ an Technological University,Xi＇ an 710021,China;School of Physical Education,Luoyang Normal University,Luoyang 471022,China)

机构地区：[1]西安工业大学体育学院,西安710021 [2]洛阳师范学院体育学院,洛阳471022

出　　处：《西安工业大学学报》2018年第4期318-323,共6页Journal of Xi’an Technological University

基　　金：陕西省体育局课题(17028;13076)

摘　　要：探讨长期持续有氧运动训练对老年大鼠骨组织保护机制.文中将F344大鼠分为三组:非运动状态的年青组(Young),非运动状态的老年大鼠组(Aged)和老年大鼠组+有氧运动(Aged+EX).运动为强度渐进的跑台运动(耐力运动),持续时间为12周.研究结果表明:长期持续有氧运动训练可以增加老年大鼠的股骨和椎骨中VDR的mRNA表达.长期持续有氧运动训练上调老年大鼠骨组织中维生素D受体的表达,该结果可以部分解释长期持续有氧运动训练对老年大鼠骨组织保护机制.The study is aimed to study the effects of chronic aerobic exercise training on bone loss in aged rats and to investigate the underlying mechanism of vitamin D receptor （VDR）. F344 rats were divided into 3 groups as follows= sedentary young rats （Young）, sedentary aged rats （Aged） and aged rats with aerobic exercise training （Aged＋ EX）. The training was performed on treadmill for 12 weeks. The study shows that chronic aerobic exercise training has enhanced the VDR mRNA levels in both femurs and vertebra of the aged rats,and can offer protection against osteoporosis in the aged rats, possibly through upregulating the expression of VDR.

关 键 词：有氧运动 老年大鼠 维生素D受体 骨质丢失 

分 类 号：G804.2[文化科学—运动人体科学]