宁夏某医院患者TB DNA检测分析  

Analysis of TB DNA in Patients in A Hospital in Ningxia

作　　者：牛宁奎[1] 王学伟[2] 施建党[1] 杨宗强[1] 丁惠强[1] NIU Ning-kui;WANG Xue-wei;SHI Jian-dang;YANG Zong-qiang;DING Hui-qiang(Department of Spinal Orthopaedicsl,Medical record Roo;General Hospital of Ningxia Medical University Ningxia 750004,Yinchuan,China)

机构地区：[1]宁夏医科大学总医院脊柱骨科,宁夏银川750004 [2]宁夏医科大学总医院病案室,宁夏银川750004

出　　处：《医学信息》2018年第16期95-97,共3页Journal of Medical Information

基　　金：国家自然科学基金项目(编号:81501903);宁夏自然科学基金(编号:NZ16157);2015年宁夏留学人员资助项目;2017年宁夏医科大学青年骨干人才培育计划项目

摘　　要：目的探讨宁夏某医院TB DNA感染现状及临床特点。方法对我院就诊的疑似结核病感染患者1828例进行回顾分析,用实时荧光定量PCR检测血浆TB DNA。结果 TB DNA阳性患者32例,总阳性率为1.75%,男、女性阳性率分别为2.17%和1.17%,差异无统计学意义(P>0.05)。童年组(0~6岁)阳性率最高为2.86%,与其他年龄组相比,差异无统计学意义(P>0.05)。春季(3~5月份)TB DNA阳性率最高为3.21%,与其他季节相比,差异有统计学意义(P<0.05)。2015年~2017年TB DNA阳性率有逐年下降趋势(2.06%、2.00%、1.16%)。TB DNA阳性患者就诊临床科室主要以泌尿外科(6.11%)、呼吸内科(5.26%)、肝胆外科(4.35%)为主。结论 TB DNA检测有助于结核病的早期诊断,为临床防治结核病提供重要依据。Objective To investigate the status and clinical characteristics of TB DNA infection in a hospital in Ningxia. Methods A retrospective analysis of 1828 patients with suspected tuberculosis infection in our hospital was performed,and plasma TB DNA was detected by real-time fluorescent quantitative PCR.Results 32 cases of TB DNA positive patients, the total positive rate was 1.75%,male and female positive rate were 2.17% and 1.17%,respectively,the difference was not statistically significant（ P〈0.05）.The highest positive rate was 2.86% in childhood group（0-6 years old）.Compared with other age groups, there was no significant difference（ P〈0.05）.In spring（March to May）,the highest positive rate of TB DNA was 3.21%,compared with other seasons,the difference was statistically significant（P〈0.05）.The positive rate of TB DNA decreased from 2015 to 2017（2.06%,2.00%,1.16%）.The clinical departments of TB DNA-positive patients were mainly urology（6.11%）,respiratory medicine（5.26%）,and hepatobiliary surgery（4.35%）.Conclusion TB DNA detection is helpful for the early diagnosis of tuberculosis and provides an important basis for clinical prevention and treatment of tuberculosis.

关 键 词：TB DNA 结核病 流行现状 

分 类 号：R52[医药卫生—内科学]