乌灵胶囊联合苄星青霉素对妊振合并梅毒患者血清RPR滴度变化及母婴结局的影响  

Effects of Wuling capsule combined with benzathine penicillin on serum rpr titer and maternal and child outcome in patients with pregnancy-induced syphilis

作　　者：黄芳[1] 李维玲[1] 陈媛媛[1] 屈萍[1] 张建芳[2] HUANG Fang;LI Weiling;CHEN Yuanyuan;QU Ping;ZHANG Jianfang(Department of Obstetrics and Gynecology,Xi ＇ an Gaoxin Hospital,Xi＇an 710075,Shaanxi,China;Department of Obstetrics and Gynecology,Xijing Hospital of the Fourth Military Medical University,Xi ＇ an 710000,Shaanxi,China)

机构地区：[1]西安高新医院妇产科,西安710075 [2]第四军医大学西京医院妇产科,西安710000

出　　处：《中国性科学》2018年第6期120-123,共4页Chinese Journal of Human Sexuality

基　　金：陕西省科技计划社会发展攻关项目(2011K12-04-05)

摘　　要：目的:探讨乌灵胶囊联合苄星青霉素对妊振合并梅毒患者血清RPR滴度变化及母婴结局的影响。方法:选取西安高新医院2014年10月至2016年6月收治的81例妊娠合并梅毒患者,按照随机数字表法分组,观察组41例给予苄星青霉素+乌灵胶囊治疗,对照组40例予以苄星青霉素治疗,观察比较两组血清RPR滴度、母体妊娠结局及新生儿结局,并统计两组不良反应发生情况及生活质量各维度(社会、躯体、心理功能、物质生活)评分。结果:观察组血清RPR滴度<1∶8者所占比例为95.12%(39/41),高于对照组62.50%(25/40),差异具有统计学意义(P<0.05);观察组不良妊娠结局发生率为7.32%(3/41),低于对照组25.00%(10/40);足月儿所占比例为92.68%(38/41),高于对照组75.00%(30/40),差异具有统计学意义(P<0.05);观察组新生儿不良结局发生率为12.20%(5/41),低于对照组30.00%(12/40);正常新生儿所占比例为87.80%(36/41),高于对照组70.00%(28/40),差异具有统计学意义(P<0.05);观察组不良反应发生率为17.07%(7/41),对照组为10.00%(4/40),组间比较差异无统计学意义(P>0.05);治疗3个月后观察组社会、躯体、心理功能及物质生活各评分均高于对照组,差异具有统计学意义(P<0.05)。结论:对妊振合并梅毒患者给予苄星青霉素与乌灵胶囊联合治疗,可改善患者血清RPR滴度、生活质量及母婴结局,用药安全性高。Objective： To investigate the effect of Wuling capsule combined with benzathine penicillin on serum RPR titer and maternal and child outcome in patients with pregnancy-induced syphilis. Methods： 81 patients with pregnancy-induced syphilisfrom October 2014 to June 2016 were selected and randomly divided into control group（ n = 40） and observation group（ n = 41）. The control group was treated with benzathine penicillin,and the observation group was treated with benzathine penicillin combined with Wuling capsule. The serum RPR titers,maternal pregnancy outcomes and neonatal outcomes were observed and compared between the two groups. Adverse events and quality of life of the various dimensions（ social,physical,psychological function,material life） scores were statistically analyzed. Results： The percentage of patients with serum RPR titer 1： 8 in the observation group was 95. 12%（ 39/41）,which was higher than that of the control group（ 62. 50%,25/40）,with statistically significant difference（ P 〈 0. 05）. The incidence of adverse pregnancy outcome in the observation group was 7. 32%（ 3/41）,lower than that of the control group（ 25. 00%,10/40）,with statistically significant difference（ P 0. 05）. The proportion of term infant in the observation group was 92. 68%（ 38/41）,higher than that of the control group（ 75. 00%,30/40）,with statistically significant difference（ P 〈 0. 05）. The incidence of neonatal adverse outcomes in the observation group was 12. 20%（ 5/41）,lower than that of the control group（ 30. 00%,12/40）,and the proportion of normal neonates in the observation group（ 87. 80%,36/41） was higher than that of the control group（ 70. 00%,28/40）,with statistically significant difference（ P 〈 0. 05）. There was no significant differencein the incidence of adverse reactions between the observation group（ 17. 07%,7/41） and the control group（ 10. 00%,4/40）（ P 〉 0. 05）. After 3 months of treatment,the scores of social,physical,p

关 键 词：妊振合并梅毒 乌灵胶囊 苄星青霉素 血清RPR滴度 母婴结局 

分 类 号：R759.154[医药卫生—皮肤病学与性病学]