中医辨证联合青霉素治疗梅毒血清抵抗的可行性与安全性  

Feasibility and safety of traditional Chinese medicine combined with penicillin in the treatment of syphilis serum resistance

作　　者：周蜜 徐萍 卢忠明[3] ZHOU Mi;XU Ping;LU Zhongming(Department of Dermatology,Shaoxing Municipal Hospital,Shaoxing 312000,Zhejiang,China;Shaoxing Third Hospital,Shaoxing 312000,Zhejiang,China;Department of Dermatology;Shengzhou People＇ s Hospital,Shaoxing 312400,Zhejiang,China)

机构地区：[1]绍兴市立医院皮肤科,浙江绍兴312000 [2]绍兴第三医院皮肤科,浙江绍兴312000 [3]嵊州市人民医院皮肤科,浙江绍兴312400

出　　处：《中国性科学》2018年第6期137-140,共4页Chinese Journal of Human Sexuality

基　　金：浙江省绍兴市柯桥区2016年医疗卫生自筹经费科技计划项目(2016KZ070)

摘　　要：目的:探究中医辨证联合青霉素治疗梅毒血清抵抗的可行性与安全性。方法:采用回顾性分析的方法,将2016年3月~2017年4月在绍兴市立医院接受治疗的60例梅毒血清抵抗患者作为研究对象,并给予随机分组,对照组30例,给予单纯青霉素治疗;干预组30例,在对照组治疗基础上给予中医辨证治疗,对两组患者治疗后的免疫功能改善情况、血清转阴情况以及血清抵抗复发情况进行综合评价。结果:干预组患者治疗后的CD4^+CD25^+T细胞显著优于对照组,两组差异具有统计学意义(P<0.05),CD4^+CD25^+,CD28^+以及CD4^+CD25^+CD152^+与对照组相比,差异不具统计学意义(P>0.05);干预组治疗后共有19例血清转阴,转阴率达到63.3%,而对照组仅有7例血清转阴,占23.3%,两组差异具有统计学意义(P<0.05);且干预组治疗后6个月,血清抵抗复发率仅为3.3%,显著低于对照组的30.0%,两组差异具有统计学意义(P<0.05)。结论:在常规青霉素治疗基础上对梅毒血清抵抗患者给予中医辨证治疗,对患者的免疫功能具有显著的改善作用,能够促进血清转阴,降低血清抵抗复发率,值得临床推广应用。Objective： To explore the feasibility and safety of traditional Chinese medicine combined with penicillin in the treatment of syphilis serum resistance. Methods： 60 patients with syphilis sero-resistance treated from March 20 to April 2017 were selected and randomly divided into 2 groups： control group（ n = 30） to receive penicillin for treatment and intervention group（ n = 30） to receive traditional Chinese medicine treatment on the basis of the control group. The improvement in immune function,serum negative conversion and the recurrence of sero-resistance were compared for comprehensive evaluation. Results： CD4＋CD25＋T cells were significantly better than those in the control group,with statistical significance（ P 〈0. 05）. The CD4＋CD25＋CD28＋and CD4＋CD25＋CD152＋were not statistically significant（ P 〉0. 05）. After treatment,there were 19 cases of serum negative,negative conversion ratio of 63. 3%,while there were only 7 cases in the control group,accounting for 23. 3%,with statistically significant difference between the two groups（ P 〈0. 05）. At 6 months after treatment,the recurrence rate was only 3. 3% in the intervention group which was significantly lower than that of the control group of 30. 0%,with statistically significant differences between groups（ P 〈0. 05）. Conclusions： Traditional Chinese medicine treatment joint conventional penicillin is conducive in improving the immune function of patients,promoting the serum negative conversion and reducing the recurrence rate of sero-resistance,which is worthy of clinical application.

关 键 词：中医辨证治疗 青霉素 梅毒血清抵抗 免疫功能 可行性 血清转阴 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]