莫西沙星联合光动力疗法治疗合并尖锐湿疣的生殖道沙眼衣原体感染的临床观察  

Clinical observation of moxifloxacin combined with photodynamic therapy forurogenital Chlamydia trachomatis infection combined with condyloma acuminatum

作　　者：贾淑青[1] 方锐华[2] 莫金雪[1] JIA Shuqing;FANG Ruihua;MO Jinxue(Department of Dermatology,Nansha Hospital of Guangzhou First People＇ s Hospital,Guangzhou 511457,Guangdong,China;Department of Dermatology,Guangzhou First People＇s Hospital,Guangzhou 510180,Guangdong,China)

机构地区：[1]广州市第一人民医院南沙医院皮肤科,广州511457 [2]广州市第一人民医院皮肤科,广州510180

出　　处：《中国性科学》2018年第6期140-143,共4页Chinese Journal of Human Sexuality

摘　　要：目的:探讨莫西沙星联合光动力疗法在治疗合并尖锐湿疣的女性生殖道沙眼衣原体感染中的疗效及安全性。方法:选取2012年5月至2017年2月来广州市第一人民医院南沙医院就诊的合并尖锐湿疣的生殖道沙眼衣原体感染患者91例,分为A组、B组和C组共3组,在均接受5-氨基酮戊酸光动力治疗的基础之上,分别接受莫西沙星、米诺环素和阿奇霉素治疗。对比3组患者的生殖道沙眼衣原体感染治愈率、疣体清除率和不良反应发生率。结果:A组患者生殖道沙眼衣原体感染治愈率分别高于B组与C组患者,其差异具有统计学意义(P<0.05)。对3组患者进行至少4周的随访,3组患者不同时间的疣体清除率差异无统计学意义(P>0.05),但治疗后3周疣体清除率均高于治疗后1周疣体清除率,其差异具有统计学意义(P<0.05)。A组患者不良反应发生率分别低于B组和C组患者,其差异具有统计学意义(P<0.05)。结论:莫西沙星联合5-氨基酮戊酸光动力治疗合并尖锐湿疣的生殖道沙眼衣原体感染患者,在保证疣体清除率的前提下,能够提高生殖道沙眼衣原体感染治愈率,降低不良反应发生率,具有临床价值。Objective： To explore the effect of moxifloxacin combined with photodynamic therapy for urogenital Chlamydia trachomatis infectioncombined with condyloma acuminatum（ CA）. Methods： 91 patients withu-rogenital Chlamydia trachomatis infection combined with CA from May 2012 to February 2017 in Guangzhou First People＇s Hospital were enrolled and divided into group A,group B and group C. The three groups were treated with moxifloxacin,minocycline and azithromycin accordingly on the basis of 5-aminolevulinic acid photodynamic therapy.The infection rate,warts clearance rate and incidence of adverse reactions were compared between the three groups.Results： The cure rate of urogenital Chlamydia trachomatis infection in group A was higher than that in group B and group C（ P 〈 0. 05）. During the over 4 weeks of follow-up,there was no significant difference in warts clearance rate between the three groups（ P 〉 0. 05）,but the warts clearance rate at the 3 rdweek was higher than that at the 1 st week after treatment（ P 〈 0. 05）. The incidence of adverse reactions in group A was lower than that in group B and group C（ P 〈 0. 05）. Conclusions： In the treatment of urogenital Chlamydia trachomatis infection combined with CA,moxifloxacin combined with photodynamic therapy can improve the cure rate of Chlamydia trachomatis infection and reduce the incidence of adverse reactions with high warts clearance rate.

关 键 词：莫西沙星 5-氨基酮戊酸光动力 尖锐湿疣 沙眼衣原体 生殖道 

分 类 号：R752.53[医药卫生—皮肤病学与性病学] R759[医药卫生—临床医学]