通脉散外敷治疗化疗性静脉炎临床疗效及其对血清炎症因子的影响  

Clinical Efficacy and Effects of Tongmai Powder External Application on Serum Inflammatory Cytokines Levels in Patients with Chemotherapeutic Phlebitis

作　　者：马婧[1] 李晓琳[1] 张清文[1] MA Jing;LI Xiao-lin;ZHANG Qing-wen(Yunnan Traditional Chinese Medicine Hospital,Kunming 650021,China)

机构地区：[1]云南省中医医院,云南昆明650021

出　　处：《中国中医药信息杂志》2018年第9期23-25,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：云南省教育厅科学研究基金项目(2016ZZX121)

摘　　要：目的观察通脉散外敷对化疗性静脉炎患者的临床疗效,探讨其对血清炎症因子的影响。方法根据入选顺序将60例化疗性静脉炎患者分为观察组和对照组各30例。观察组将通脉散均匀涂于纱布,厚度0.5~1 cm,面积稍大于病变部位,外敷并用胶布固定。对照组予硫酸镁湿敷,每日2次,每次不少于2 h。均3 d为1个疗程,连续治疗3个疗程。观察2组患者临床疗效及视觉模拟评分(VAS),检测治疗前后2组患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-4、IL-8和IL-10水平。结果观察组总有效率为96.67%(29/30),对照组为83.33%(25/30),观察组疗效明显优于对照组(P=0.007)。与本组治疗前比较,2组治疗后VAS明显降低,观察组治疗后血清TNF-α、IL-8水平明显下降,IL-4、IL-10水平明显升高(P<0.05)。2组治疗后比较,观察组VAS低于对照组(P<0.05),TNF-α、IL-8水平低于对照组(P<0.05),IL-4和IL-10水平高于对照组(P<0.05)。结论通脉散外敷治疗化疗性静脉炎疗效显著,其机制可能与调节炎症因子平衡相关。Objective To investigate the clinical efficacy and effects of Tongmai Powder external application on serum inflammatory cytokines levels in patients with chemotherapeutic phlebitis. Methods Totally 60 patients with chemotherapeutic phlebitis were randomly divided into observation group and control group by order of inclusion, with 30 cases in each group. The observation group was treated with Tongmai Powder. The Tongmai Powder was evenly applied to the gauze. The thickness was 0.5–1 cm. The area was slightly larger than the lesion. The gauze was applied externally to the lesion and fixed with tape. The control group was given magnesium sulfate, twice a day for not less than 2 hours. 3 d was one treatment course for both groups, for successive three courses. Clinical efficacy and VAS of both groups were observed. The levels of TNF-α, IL-4, IL-8 and IL-10 before and after treatment in the two groups were compared. Results The total effective rate was 96.67%（29/30） in the observation group and 83.33%（25/30） in the control group. The observation group was significantly better than the control group（P=0.007）. Compared with before treatment, the VAS of the two groups were significantly lower. The serum levels of TNF-α and IL-8 in the observation group decreased significantly, and the levels of IL-4 and IL-10 increased significantly（P0.05）. After treatment, the VAS was lower in the observation group than in the control group（P0.05）, the levels of TNF-α and IL-8 were lower in the observation group（P0.05） and the IL-4 and IL-10 levels were higher than the control group（P0.05）. Conclusion Tongmai Powder external application can effectively treat chemotherapeutic phlebitis, which mechanism may be related to regulating the balance of inflammatory cytokines.

关 键 词：通脉散 化疗性静脉炎 炎症因子 

分 类 号：R269.543[医药卫生—中西医结合]