职业性接触氰戊菊酯农药对精液质量的影响  

Effects of Fenvalerate Exposure on the Semen Quality of Occupational Workers

作　　者：谈立峰[1,2] 王守林[1] 孙雪照[3] 李燕南[3] 王茜丽[3] 吉俊敏 陈龙生[4] 王心如[1] 

机构地区：[1]南京医科大学公共卫生学院 [2]常州市疾病预防控制中心,江苏常州213003 [3]常州市疾病预防控制中心 [4]常州市卫生局

出　　处：《中华男科学杂志》2002年第4期276-276,共1页National Journal of Andrology

基　　金：常州市科委资助项目 (CL0 13 0 13 ) ;江苏省疾病预防控制中心资助项目 (Y2 0 0 2 0 2 4)

摘　　要：目的 :探讨氰戊菊酯农药对男性工人精液质量的影响 ,寻找早期效应性生物标志物。　方法 :分别选择某农药厂氰戊菊酯生产男性工人 32名为暴露组 ,厂行政办公区男性工作人员 4 6名为内对照组 ,另选择某疾病控制中心男性工作人员 2 2名为外对照组。对各组环境空气中氰戊菊酯及其相关溶剂如甲苯、二甲苯进行连续 3d的监测 ,评价暴露水平 ;按统一的实施标准收集一次性精液 ,用美国加州大学戴维斯分校 (UCDavis)推荐的方法对精液质量进行评价 ,同时应用计算机辅助精子分析系统 (CASA)对精子的运动能力进行分析。　结果 :暴露组空气中氰戊菊酯浓度明显高于内、外对照组 (P <0 .0 1) ,而甲苯、二甲苯浓度差异无显著性 (P >0 .0 5 ) ;暴露组精子总数、精子运动直线性 (LIN)、精子运动前向性 (STR)均显著低于内、外对照组 (P <0 .0 5 ) ;精液粘稠度、凝集度及精子总数异常率显著高于内、外对照组 (P <0 .0 5 ) ;精子活动度、鞭打频率 (BCF)显著低于外对照组 (P <0 .0 5 ) ,活动度异常率显著高于外对照组 (P <0 .0 5 )。　结论Objectives: To study the effects of fenvalerate exposure on the semen quality of occupational workers in order to find out the early effective biomarkers. Methods: Thirty two male workers who exposed to fenvalerate and 46 male administrators in the office in a pesticide factory were selected as the exposure group and internal control group, respectively, and 22 male administrators in a center for disease control were served as the external control group.In order to evaluate the exposed levels, the concentration of fenvalerate, toluene and xylene in the ambient air of working place in these three groups were monitored simultaneously for three consecutive days. After the semen were collected according to the standard method, the workers' semen qualities were analysed with University of California at Davis (UCDavis) method and the sperm motility were evaluated using computer assisted sperm analysis(CASA). Results: In the exposure group, the concentrations of fenvalerate were significantly higher than those in the internal and external control group ( P <0.01), while no significant difference of the concentration on toluene or xylene was found ( P >0.05).Sperm motion parameters in the exposure group such as linearity(LIN),straightness(STR), and the sperm count were decreased significantly, and the abnormality rate of viscidity, coagulation and sperm count were increased significantly as compared with the internal and the external control groups( P <0.05). Furthermore, the sperm progression and beat cross frequency (BCF) in the exposure group were also lower significantly than those in the external control group( P <0.05), while the abnormality rate of sperm progression was increased significantly. Conclusions: In such a low concentration, occupational exposure to fenvalerate can affect workers' semen quality, especially the sperm count and sperm movement ability.

关 键 词：氰戊菊酯 职业暴露 精液质量 计算机辅助精子分析 

分 类 号：R139[医药卫生—劳动卫生]