肥胖对支气管哮喘患儿炎症平衡状态及肺损害的影响  

Effect of obesity on inflammatory balance state and lung injury in children with bronchial asthma

作　　者：马春利[1] 薛满 刘伟华[2] MA Chun-li;XUE Man;LIU Wei-hua(Department of Pediatrics,Baoji People＇s Hospital;Department of Pediatrics,The First Hospital of Xi＇an City,Xi＇an Shaanxi 710000,China)

机构地区：[1]陕西省宝鸡市人民医院儿科,陕西宝鸡721099 [2]西安市第一医院儿科,陕西西安710000

出　　处：《临床和实验医学杂志》2018年第17期1900-1903,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨肥胖对支气管哮喘(BA)患儿炎症平衡状态及肺损害的影响。方法回顾性分析2014年6月至2017年6月陕西省宝鸡市人民医院收治的100例BA患儿的病例资料,依据体重指数(BMI)分为肥胖组(BMI>21kg/m^2,n=36)和正常组(BMI≤21 kg/m^2,n=64例),所有患儿均行肺功能检查用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、呼气峰流速(PEF)、采用酶联免疫吸附试验检测血清IL-5、IL-6、IL-10,并记录急性发作频率,分析BMI与IL-5、IL-6、IL-10、急性发作频率的关系。结果肥胖组FVC、FEV1、PEF、IL-10[(1.56±0.19)L、(1.32±0.15)L、(2.82±0.37)L/s、(15.85±1.82)ng/L]明显低于正常组[(1.84±0.20)L、(1.58±0.18)L、(3.51±0.46)L/s、(22.31±2.34)ng/L],肥胖组BMI、IL-5、IL-6、急性发作频率[(22.34±2.27)kg/m^2、(146.21±16.21)ng/L、(96.21±10.21)ng/L、(9.57±1.18)次/月]明显高于正常组[(18.25±2.01)kg/m^2、(115.37±12.27)ng/L、(84.25±8.87)ng/L、(6.87±0.85)次/月],差异具有统计学意义(P<0.05);Pearson相关性分析结果显示,BMI与IL-5、IL-6、急性发作频率呈正相关,与IL-10呈负相关(P<0.05)。结论肥胖可能会引起BA患儿炎症平衡状态失衡,促进肺部炎症反应而加重肺损害,增加患儿急性发作的风险。Objective To discuss the effect of obesity on inflammatory balance state and lung injury in children with bronchial asthma（ BA）. Methods From June 2014 to June 2017,100 cases children with BA were selected in Shaanxi Baoji People＇s Hospital of Shaanxi Province,according to body mass index（ BMI） they were divided into obesity group（ BMI 21 kg/m^2,n = 36） and normal group（ BMI≤21 kg/m^2,n = 64）,the pulmonary function test（ FVC）,forced vital capacity 1 s forced expiratory volume（ FEV1）,peak expiratory flow（ PEF） of all patients were detected,the serum IL-5,IL-6,IL-10 were detected by enzyme-linked immunosorbent assay and the frequency of acute exacerbation were recorded,the relationship between BMI and IL-5,IL-6,IL-10,the frequency of acute exacerbation were analyzed. Results The FEV1,PEF,FVC,IL-10 in obesity group [（ 1. 56 ± 0. 19） L,（ 1. 32 ± 0. 15） L,（ 2. 82 ± 0. 37） L/s,（ 15. 85 ± 1. 82） ng/L] were significantly lower than those in normal group [（ 1. 84 ± 0. 20） L,（ 1. 58 ± 0. 18） L,（ 3. 51 ± 0. 46） L/s,（ 22. 31 ± 2. 34） ng/L],the IL-5,IL-6,BMI,the frequency of acute exacerbation in obesity group [（ 22. 34 ± 2. 27） kg/m^2,（ 146. 21 ± 16. 21） ng/L,（ 96. 21 ± 10. 21） ng/L,（ 9. 57 ± 1. 18） times/month]were significantly higher than those in normal group [（ 18. 25 ± 2. 01） kg/m^2,（ 115. 37 ± 12. 27） ng/L,（ 84. 25± 8. 87） ng/L,（ 6. 87 ± 0. 85） times/month],the difference was statistically significant（ P〈0. 05）. Pearson correlation analysis showed that,BMI was positively correlated with IL-5,IL-6,the frequency of acute exacerbation,and it was negatively correlated with IL-10（ P〈0. 05）.Conclusion Obesity may cause imbalance of inflammatory balance in children with BA,it can promote lung inflammatory reaction and aggravate lung damage,and it can increase the risk of acute attack in children.

关 键 词：支气管哮喘 肥胖 炎症平衡状态 肺损害 

分 类 号：R725.6[医药卫生—儿科] R723.14[医药卫生—临床医学]