阻塞性呼吸暂停低通气综合征持续正压通气治疗随访研究  

Follow-up study of continuous positive airway pressure in obstructive apnea-hypopnea syndrome

作　　者：朱盈盈[1] 陈巧玲[1] 朱吉鹏[1] 李新[1] 郭文贤[1] ZHU Ying-ying;CHEN Qiao-ling;ZHU Ji-peng;LI Xin;GUO Wen-xian(Department of General,Zhongshan Hosptial Affiliated to Guangzhou Traditional Chinese Medical University,Zhong-shan 528400,Chin)

机构地区：[1]广州中医药大学附属中山医院综合科,广东中山528400

出　　处：《中国当代医药》2018年第23期56-59,共4页China Modern Medicine

基　　金：广东省中山市医学科研项目(2016A020346)

摘　　要：目的观察阻塞性睡眠呼吸暂停低通气综合征患者中使用持续正压通气治疗后血液生化指标、血压、Epworth量表评分变化情况,从而评估持续正压通气治疗的临床疗效。方法选取我院2015年1月~2016年1月收治的阻塞性睡眠呼吸暂停低通气综合征患者100例,最终纳入病例92例,采用随机数字表法将其分为治疗组47例,对照组45例。治疗组予持续正压通气治疗,观察治疗周期为30 d,对照组予常规对症治疗,并在观察周期结束后予查两组患者的血脂、超敏C反应蛋白(hs-CRP)、同型半胱氨酸(HCY)、红细胞分布宽度水平、血压及Epworth评分改善情况。观察并比较两组的相关指标的水平变化。结果两组治疗前的低密度脂蛋白(LDL)、总胆固醇(TG)水平比较,差异无统计学意义(P>0.05)。治疗组患者治疗后总胆固醇水平及红细胞分布宽度水平低于本组治疗前,差异有统计学意义(P<0.05)。治疗组治疗后LDL、hs-CRP、HCY水平比较,差异无统计学意义(P>0.05)。治疗组患者治疗后的TG水平及红细胞分布宽度水平低于对照组,差异均有统计学意义(P<0.05)。治疗组治疗后睡前及晨起收缩压水平低于本组治疗前,差异有统计学意义(P<0.05);治疗组治疗后睡前及晨起舒张压水平与本组治疗前的比较,差异均无统计意义(P>0.05);治疗前,两组血压水平的比较,差异均无统计意义(P>0.05);对照组治疗前后血压水平的比较,差异均无统计意义(P>0.05)。两组患者治疗前Epworth嗜睡量表评分的比较,差异无统计学意义(P>0.05);治疗组治疗后Epworth嗜睡量表的评分低于本组治疗前,且治疗组治疗后Epworth嗜睡量表评分低于对照组,差异均有统计学意义(P<0.05)。对照组治疗前后的比较,差异均无统计学意义(P>0.05)。结论持续正压通气治疗对阻塞性呼吸暂停低通气综合征患者血压控制、改善心肌缺血、脂代谢及生活质量具有良好效果。Objective To observe the changes of blood biochemical parameters, blood pressure and Epworth scale scores in patients with obstructive sleep apnea-hypopnea syndrome after continuous positive airway pressure therapy, so as to evaluate the clinical efficacy of continuous positive airway pressure therapy. Methods A total of 100 patients with obstructive sleep apnea hypopnea syndrome admitted to our hospital from January 2015 to January 2016 were selected.Finally, 92 cases were included. By a random number table method, they were divided into treatment group（n=47）and control group（n=45）. In the treatment group, continuous positive pressure ventilation was adopted, and the observation period was 30 days. In the control group, routine symptomatic treatment was used. After the end of the observation period, the blood lipids, C-reactive protein（CRP）, homocysteine（HCY）, and red blood cell distribution width level, blood pressure, and Epworth score improvement were observed and compared in the two groups. Results There was no significant difference in the levels of low density lipoprotein（LDL） and total cholesterol（TC） before treatment between the two groups（P〈0.05）. After treatment, the TC level and the distribution width of red blood cells in the treatment group were lower than those before treatment with statistical differences（P〈0.05）. Before and after treatment, there was no significant difference in the levels of LDL, hs-CRP and HCY in the treatment group（P〈0.05）. After treatment the TC level and the distribution width of red blood cells in the treatment group were lower than those in the control group with significant differences（P〈0.05）. After treatment, the systolic blood pressure in the treatment group was lower than that before treatment（P〈0.05）. There was no statistical difference between the diastolic blood pressure levels before and after treatment in the treatment group and those before treatment in this group（P〈0.05）.Before treatment, there was no

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 持续正压通气 血压 指标 随访 

分 类 号：R473[医药卫生—护理学]