β—内啡肽与泌乳素在内异症不孕中的变化研究  

The Role of Beta-endorphin and PRL in endometriosis associated infertility.

作　　者：杨映芳[1] 徐琳[1] 王秀丽[1] 李庆云[2] 单朝屏 董文漪[1] 

机构地区：[1]昆明医学院附属第一医院妇产科,云南昆明650031 [2]昆明医学院附属第一医院核医学科,云南昆明650031

出　　处：《云南医药》2002年第4期270-273,共4页Medicine and Pharmacy of Yunnan

摘　　要：目的　通过对子宫内膜异位症不孕状态下 β—内啡肽 (β—EP)和泌乳素 (PRL)水平的测定及其相关性分析 ,初步探讨 β—EP对PRL分泌的影响在内异症不孕发生中的可能作用。 方法　以内异症不孕患者为研究对象 ,内异症妊娠、输卵管阻塞性不孕和正常妇女为对照组 ,检测卵泡晚期或黄体期血浆 β—EP和血清PRL水平 ,进行对比研究并分析 β—EP与PRL水平变化的相关性。 结果　 1 内异症不孕和内异症妊娠妇女无论卵泡晚期或黄体期血浆 β—EP和血清PRL水平都升高 (P <0 0 1 ) ,内异症不孕患者变化较内异症妊娠妇女明显 (P <0 0 5)。 2 内异症不孕和内异症妊娠妇女无论卵泡晚期或黄体期 β—EP与PRL水平的变化都具有相关性 (P <0 0 5)。 结论　内异症患者 β—EP和PRL水平明显增高 ,PRL水平增高与 β—EP有关 。Objective To investigate the possible effect of Beta-endorphin(β-EP) and PRL in the aetiology of endometriosis associated infertility(EAI).Method Blood was drawn from the patiens of EAT, EMT, tubal factor infertility and normal women during the follicular phase or luteal phase to determine the concentrations of β-EP and PRL. We also analyze the correlation between β-EP and PRl. Result The concentrations of β-EP and PRL in the blood of EAI and EMT patients are higher(P<0.05) than the contrasts regardless of follicular phase and luteal phase. These changes are more obvious (P<0.05) in EAI women. Conclusion There is a significant correlation between the concentration of β-EP and PRL. The secretions of β-EP and PRL are raised in EAI and EMT. β-EP correlates with the secretion of PRL are the possible reasons which result in the EAI.

关 键 词：子宫内膜异位症 Β-EP PRL β-内啡肽 泌乳素 不孕 

分 类 号：R711.6[医药卫生—妇产科学] R711.71[医药卫生—临床医学]