4周爬梯抗阻训练对低氧诱导大鼠骨骼肌萎缩的影响  

Effects of 4-week resistance training on hypoxia-induced skeletal muscle atrophy in rats

作　　者：于加倍 胡扬[1] 李燕春[1] 梅涛[1] 韩天雨 白学成 付鹏宇[1] 朱镕鑫 车欣媛 YU Jiabei;HU Yang;LI Yanchun;MEI Tao;HAN Tianyu;BAI Xuecheng;FU Pengyu;ZHU Rongxin;CHE Xinyuan(Beijing Sport University,Beijing 100084,China)

机构地区：[1]北京体育大学,北京100084

出　　处：《中国实验动物学报》2018年第4期448-453,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金面上项目(No.31771317)~~

摘　　要：目的探究抗阻训练抵抗低氧诱导骨骼肌萎缩的效果,为解决高原训练期间运动员骨骼肌丢失问题提供理论依据。方法 8周龄雄性Sprague-Dawley(SD)大鼠24只,平均体重约230 g,随机分为4组:常氧安静组(C)、常氧抗阻训练组(R)、低氧安静组(H)和低氧抗阻训练组(HR)。H和HR组在模拟海拔4000 m,R和HR组则进行抗阻训练,进行4周的低氧及抗阻训练干预后测试各组大鼠体成分,比目鱼肌、趾长伸肌、腓肠肌、肱二头肌的湿重和肌纤维横截面积。结果观察到HR组瘦体重显著高于H组,H组瘦体重显著低于C组;HR组的肱二头肌湿重和肌纤维横截面积显著高于H组。结论抗阻训练有助于预防低氧诱导骨骼肌萎缩的发生,爬梯形式的抗阻练习可刺激大鼠肱二头肌的肥大。Objective To explore the effects of resistance training on hypoxia-induced skeletal muscle atrophy in rats and provide a theoretical basis to solve the problem of skeletal muscle atrophy of athletes in altitude training. Methods24 male 8-week-old SD rats（ mean body weight 230 g） were divided into 4 groups： normoxia control group（ C）,resistance training group（ R）,hypoxia group（ H） and hypoxia and resistance training group（ HR）. The groups H and HR were placed into environment simulated 4000 m altitude（ 12. 4%,O_2%）. Moreover,the groups R and HR received resistance training. After the 4-week hypoxia and resistance training intervention,the body composition,wet weight of skeletal muscle（ soleus,musculus gastrocnemius,extensor digitorum longus and musculus biceps brachii） and skeletal muscle crosssectional area（ CSA） were measured and analyzed. Results The muscle mass of HR group was significantly higher than the group H（ P〈 0. 01）. The wet weight and CSA of musculus biceps brachii in the group HR were also significantly higher than the group H（ P〈 0. 05）. Conclusions Resistance training can help to prevent the occurrence of hypoxiainduced skeletal muscle atrophy. Resistance ladder training can stimulate the hypertrophy of biceps brachii.

关 键 词：SD大鼠 骨骼肌萎缩 低氧 爬梯抗阻训练 

分 类 号：Q95-33[生物学—动物学]