NSAIDs所致阿司匹林哮喘的文献分析  

Literature Analysis of Aspirin Induced Asthma Result from NSAIDs

作　　者：张小丁 周域 王晓刚[1] 方子涵 ZHANG Xiao-ding;ZHOU Yu;WANG Xiao-gang;FANG Zi-han(College of Chemistry and Bio-engineering,Yichun University,Yichun 336000,China)

机构地区：[1]宜春学院化学与生物工程学院,江西宜春336000

出　　处：《宜春学院学报》2018年第6期19-23,共5页Journal of Yichun University

摘　　要：目的:了解阿司匹林哮喘(AIA)的流行病学情况,为临床AIA的防治提供参考。方法:以"阿司匹林、诱发/引起/导致、哮喘"、"NSAIDs、诱发/引起/导致、哮喘"等为关键词检索发表在中国知网、中国万方、维普数据库中所有报道AIA的相关文献,再从药品种类、发作时间等方面进行分析总结。结果:诱发AIA的NSAIDs药物共涉及8类,主要为水杨酸类(24例)、吲哚类(19例)和芳基丙酸类(14例),诱发AIA少见的药物为醋氨酚(扑热息痛)、甲氧萘丙酸(萘普生)等。共收录病例81例,其中有哮喘及喘息性疾病史的33例占总比40.74%,合并有鼻息肉及鼻炎等鼻部疾病的17例占总比20.98%。各个年龄段均有发病可能,19~60岁多见(60例,74.07%)。女性病例(37例,45.67%),男性病例(42例,51.85%),性别差异无统计学意义(P>0.05)。AIA发作间隔时间以2h以内最多见(65例,80.24%)。主要给药途径为口服(66例,81.48%),未发现药物给药途径与AIA发作间隔时间之间有明显关联。结论:临床使用NSAIDs前应对患者疾病史及过敏史做充分了解,使用NSAIDs后应至少密切关注患者2h内生命体征变化,AIA急性发作时常有生命危险,应做到及时发现、治疗。Objective： To understand the epidemiology of aspirin Induced asthma（ AIA） and provide reference for the prevention and treatment of clinical AIA. Methods： The relevant articles of AIA published in China Knitting Network,China Wanfang,VIP database were searched with the key words ＂aspirin,induced/induced/induced,asthma＂,＂NSAIDs,induced/induced/induced＂,Then from the types of drugs,attack time and other aspects of analysis and summary. Results： There were 8 classes of NSAIDs induced by AIA,including salicylates（ 24 cases）,indole（ 19 cases） and arylpropionic acids（ 14 cases）. The drugs that induced AIA were acetaminophen（ Paracetamol）,naproxen（ naproxen） and so on. A total of 81 cases were included,of which 33 cases（ including 6 cases of severe aspirin asthma,3 cases of death） with history of asthma and wheezing accounted for 40. 74%,17 cases of nasal diseases with nasal polyps and rhinitis Accounting for more than 20. 98%. Incidence of all age groups are likely,19 to 60 years of age more common（ 60 cases,74. 07%）. Female cases（ 37 cases,45. 67%）,male cases（ 42 cases,51. 85%）,gender differences was not statistically significant（ P〉0.05）. AIA seizure interval within 2 h to see the most（ 65 cases,80. 24%）. The main route of administration was oral（ 66 cases,81. 48%）,and no clear correlation was found between the route of administration of drugs and the interval of AIA episodes. Conclusions： The clinical history of NSAIDs and the history of allergy should be fully understood before using NSAIDs. At least 2-hour vital signs should be observed after using NSAIDs. AIA is often life-threatening and should be detected and treated promptly.

关 键 词：非甾体抗炎药(NSAISDs) 阿司匹林哮喘 文献分析 

分 类 号：R562[医药卫生—呼吸系统]