槟榔对健康人胃肠动力的作用研究  

Effect of areca-nut on gastrointestinal motility in healthy people

作　　者：蒋志 曹立幸 陈其城 张骏鸿 周吕[3] 陈志强 Jiang Zhi;Cao Lixing;Chen Qicheng;Zhang Junhong;Zhou Lyu;Chen Zhiqiang(Department of Perioperative TCM,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510120,China)

机构地区：[1]广州中医药大学第二附属医院围手术期中医药应用研究团队,广州510120 [2]广州中医药大学第二附属医院公共实验室,广州510120 [3]中国协和医科大学基础医学研究所

出　　处：《中华生物医学工程杂志》2017年第6期464-469,共6页Chinese Journal of Biomedical Engineering

基　　金：广东省中医药局（20164021、20181103）;广州中医药大学高水平大学研究项目（[2016]Al-AFD01816lzl520）;广东省中医院中医药科学技术研究专项（YN2016QJl8）

摘　　要：目的观察槟榔对健康志愿者胃肠动力及血浆胃动素、胃促生长素（ghrelin）水平的影响。方法30例志愿者按2：1随机分为槟榔组（n=20）和安慰剂组（n=10）。使用Solar GI胃肠动力仪进行高分辨率测压检测胃肠动力。两组志愿者空腹测压4h后，分别口服槟榔煎剂或安慰剂，观察给药前后胃肠动力变化。采用酶联免疫吸附法（ELISA）检测给药前后两组志愿者血浆胃动素、ghrelin水平。结果与安慰剂组比较，槟榔组给药后胃肠消化间期移行性复合运动（MMC）Ⅰ相时程缩短51％（P〈0．001），MMClI相时程延长298％（P〈0．001）。槟榔组给药后远端胃、十二指肠、空肠MMC Ⅱ相振幅较安慰剂组分别增加49％、28％、28％，差异均有统计学意义（均P〈0．05）；槟榔组远端胃、十二指肠、空肠MMC Ⅲ相动力指数较安慰剂组分别增加54％、52％、37％，差异均有统计学意义（均P〈0．05）。槟榔组给药后远端胃、十二指肠、空肠MMC Ⅱ相振幅较安慰剂组分别增加64％、28％、13％（均P〈0．05）；槟榔组给药后远端胃、十二指肠、空肠MMC Ⅱ相动力指数较安慰剂组分别增加138％、830％、531％（均P〈0．05）。槟榔组给药后MMC周期缩短16％（P=0．048），MMC Ⅰ相时程缩短51％（P〈0．001），MMCⅡ相时程延长298％（P〈0．001）。槟榔组给药后远端胃MMC Ⅲ相振幅较给药前显著增加，十二指肠、空肠Ⅲ相时程较给药前显著增加（均P〈0．05）。槟榔组给药后远端胃、十二指肠、空肠Ⅱ相振幅较给药前均显著增加（均P〈0．05）；给药后远端胃、十二指肠、空肠Ⅱ相动力指数较给药前分别增加102％、262％、215％（均P〈0．05）。与给药前比较，槟榔组给药后可显著增加血浆胃动素、ghrelin水平（均P〈0．05）。与安慰剂组比较，给药后槟榔组血浆胃动索、ghrelin水平显著增加（均P〈0．05）。Objective To assess the effects of areca-nut on gastrointestinal motility （GIM） , plasma motilin and ghrelin levels in healthy volunteers. Methods A total of 30 volunteers were randomly divided into areca-nut group （n=20） and placebo group （n=10） according to a ratio of 2： 1. The GIM was measured via high resolution antroduodenojejunal manometry using a Solar GI motility instrument. Two groups of volunteers were treated with oral areca-nut decoction or placebo at 4 h after the fasting manometry. The changes in GIM before and after treatment were examined. Enzyme-linked immunosorbent assay was used to detect the plasma motilin and ghrelin levels in both groups before and after the oral administration. Results Compared with the placebo group, the interdigestive migrating motor complex （MMC） Ⅰ phase in the areca-nut group was shortened by 51% （P〈0.001） , and the MMC Ⅱ phase prolonged by 298% （P〈0.001 ）. The post-treatment amplitudes of MMC Ⅲ phase in the distal stomach, duodenum, and jejunum in the areca-nut group were increased by 49%, 28%, and 28%, respectively, compared with the placebo group （all P〈0.05）. The motility indexes of MMC Ⅲ phase in distal stomach, duodenum, and jejunum of the areca-nut group increased by 54%, 52% and 37% after treatment, respectively, compared with the placebo group, showing statistically significant difference （all P〈0.05）. In the areca-nut group, the post-treatment amplitudes of MMC Ⅱ phase in the distal stomach, duodenum, and jejunum were increased by 64%, 28%, and 13%, respectively, compared with the placebo group （all P〈0.05）. The post-treatment motility indexes of MMC Ⅱ phase in the distal stomach, duodenum, and jejunum in the areca-nut group increased by 138%, 830%, and 531%, respectively, compared with the placebo group （all P〈0.05）. After treatment, the areca-nut group showed shortened MMC cycle by 16% （P=0.048）, shortened MMC I phase by 51% （P〈0.001）, and prolonged MMC Ⅱ phase by 298% （P〈0.001

关 键 词：槟榔 胃肠病用药(中药) 胃肠动力 胃动素 胃促生长素 

分 类 号：Q[生物学]