腹膜透析患者血清脂联素与炎症及血管钙化的相关性  

Correlation of serum adiponectin with inflammation and vascular calcification in peritoneal dialysis patients

作　　者：胡国强[1] 钟雪莺[1] 姜松青[1] 石晓峰[1] 苏明[1] HU Guo-qiang;ZHONG Xue-ying;JIANG Song-qing;SHI Xiao-feng;SU Ming(Department of Nephrology,Jiangmen Central Hospital,Jiangmen 529000,China)

机构地区：[1]广东省江门市中心医院肾内科,广东江门529000

出　　处：《广东医科大学学报》2018年第2期190-193,共4页Journal of Guangdong Medical University

摘　　要：目的探讨维持性腹膜透析(CAPD)患者血清脂联素(ADPN)与炎症及血管钙化的相关性。方法选择CAPD患者130例,根据是否合并血管钙化分为钙化组和非钙化组,比较两组患者的临床资料、糖脂代谢、炎症因子、ADPN的差异。结果 CAPD患者中有62.3%发生血管钙化,钙化组患者年龄、透析龄均大于非钙化组,差异有统计学意义(P<0.05或0.01);钙化组患者血清甘油三脂(TG)、炎症因子C反应蛋白(CRP)、IL-6、TNF-α水平均高于非钙化组,血清白蛋白(Alb)、高密度脂蛋白(HDL)、ADPN水平则低于非钙化组,差异有统计学意义(P<0.05)。钙化组患者血清ADPN与HDL呈正相关(r=0.317,P<0.05),与CRP、IL-6、TNF-α呈负相关(r=-0.391、-0.236、-0.554,P<0.05或0.01);ADPN与年龄、透析龄、BMI、Alb、Glu、TC、TG、LDL的相关性不显著(P>0.05)。结论 ADPN可能通过抑制CAPD患者的炎症反应,改善脂代谢,从而抑制血管钙化。Objective To investigate the correlation of serum adiponectin（ADPN） with inflammation and vascular calcification in the patients with continuous ambulatory peritoneal dialysis（CAPD）. Methods 130 CAPD patients were divided into Calcification Group and Non-Calcification Group based on whether there is vascular calcification. The clinical data, glucolipid metabolism, inflammatory factor and ADPN of the two groups were compared. Results 62.3% of CAPD patients had vascular calcification. The Calcification Group had their age and dialysis age greater than Non-Calcification Group, and the difference was statistically significant（P〈0.05 or 0.01）; The Calcification Group had the triglyceride（TG）, C reactive protein（CRP）, interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） level higher than Non-Calcification Group and the albumin（Alb）, high-density lipoprotein（HDL） and ADPN level lower than Non-Calcification Group, and the difference was statistically significant（P〈0.05）. In Calcification Group, the serum ADPN was positively correlated to HDL（r=0.317, P〈0.05）, but negatively correlated to CRP, IL-6 and TNF-α（r=-0.391,-0.236 and-0.554, P〈0.05 or 0.01）. There were no correlation of ADPN with the age, dialysis age, BMI, Alb, Glu, TC, TG and LDL（P〉0.05）. Conclusion ADPN may inhibit inflammatory reaction in CAPD patients, improve lipid metabolism, and thus inhibit vascular calcification.

关 键 词：腹膜透析 脂联素 炎症 血管钙化 

分 类 号：R692.5[医药卫生—泌尿科学]