氟比洛芬酯脂微球注射液对大鼠坐骨神经损伤的保护作用  

Protective effect of flurbiprofen axetil injection on sciatic nerve injury in rats

作　　者：刘堂红 何敏 毛婷婷 杨玉宇 张玮 曹殿青 许碧莲 LIU Tang-hong;HE Min;MAO Ting-ting;YANG Yu-yu;ZHANG Wei;CAO Dlan-qlng;XU Bi-lian(Guangdong Medical University,Zhanjiang 524023,China;Department of Anesthesiology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China;Department of Pharmacology,Guangdong Medical University,Zhanjiang 524023,China)

机构地区：[1]广东医科大学,广东湛江524023 [2]广东医科大学附属医院麻醉科,广东湛江524001 [3]广东医科大学药理教研室,广东湛江524023

出　　处：《广东医科大学学报》2018年第1期53-55,共3页Journal of Guangdong Medical University

摘　　要：目的观察氟比洛芬酯脂微球注射液(商品名凯纷)对大鼠坐骨神经损伤的作用。方法 40只雌性SD大鼠随机分成4组:A组(空白对照组)不作任何处理,B组(生理盐水组)给予生理盐水,C组(利多卡因组)给予2%利多卡因进行坐骨神经周围注射,D组(利多卡因+凯纷组)在注射利多卡因30 min后注射凯纷。观察各组大鼠的神经功能损伤情况,检测血清和神经组织中丙二醛含量,并作坐骨神经病理学检查。结果 C组中血清MDA含量高于B、D组(P<0.05),而各组神经组织中丙二醛含量差异无统计学意义(P>0.05)。C组中坐骨神经损伤评分高于A、B、D组(P<0.01)。结论氟比洛芬对大鼠坐骨神经损伤具有一定的保护作用。Objective To observe the effect of flurbiprofen axetil injection（Kaifen） on sciatic nerve injury in rats.Methods Forty female SD rats were randomly divided into four groups. Groups A（blank control group）, B（saline group）, C（lidocaine group）, and D（lidocaine ＋ Kaifen group） were injected with nothing, saline, 2% lidocaine around the sciatic nerve, and flurbiprofen 30 minutes after lidocaine injection. The neurological impairment, serum and neural content of malondialdehyde, and pathological examination of sciatic nerve were performed in all groups. Serum level of malondialdehyde Results was higher in Group C than in Groups B and D（P〈0.05）, while neural level of malondialdehyde was comparable among all groups（P〉0.05）. The neurological impairment of sciatic nerve was increased in Group C compared with Groups A, B and D（P〈0.01）. Flurbiprofen can provide a protective effect on the sciatic nerve injury in rats.Conclusion

关 键 词：利多卡因 坐骨神经损伤 氟比洛芬 神经保护 

分 类 号：R614[医药卫生—麻醉学]