肾病综合征型妊娠期高血压疾病84例临床分析  

Clinical analysis on pregnancy-induced hypertension with nephrotic syndrome:84 cases

作　　者：陈伟萍[1] 黄泳华[1] 张群[1] 冯穗华[1] 卢雅苹[1] 王加[1] CHEN Wei-ping;HUANG Yong-hua;Zhang Qun;FENG Sui-hua;LU Ya-ping;WANG Jia(Department of Obstetrics and Gynecology,Jiangmen Central Hospital,Jiangmen 529000,China)

机构地区：[1]广东省江门市中心医院产科,广东江门529000

出　　处：《广东医科大学学报》2018年第3期323-326,共4页Journal of Guangdong Medical University

基　　金：江门市科技计划项目(No.2013019;20160203)

摘　　要：目的探讨肾病综合征型妊娠期高血压疾病(NSP)的临床特征及其对母婴的影响。方法分析84例NSP(NSP组)和162例未合并肾病综合征的重度子痫前期患者(对照组)的临床资料,并对比两组孕周、临床特点、生化指标、凝血功能、D-二聚体及母婴预后的差异。结果 NSP组发病孕周早,出现重度水肿、腹水及眼底改变症状者较对照组多(P<0.01),低蛋白血症、24 h尿蛋白定量、高凝状态、肾功能受损和母婴并发症、NSP组围生儿发病率和病死率均高于对照组(P<0.01)。结论肾病综合征型妊娠期高血压疾病发病早,必须严密监控和动态监测母婴情况,改善母婴预后。Objective To investigate the clinical characteristics of pregnancy-induced hypertension with nephrotic syndrome（NSP） and their effect on mother and infant. Methods The clinical data of the 84 cases of pregnancy induced hypertension with nephrotic syndrome（Group NSP） and 162 cases of severe pregnancy-induced hypertension not combined with nephrotic syndrome（Control Group） were retrospectively analyzed. The difference in the gestational week, clinical characteristics, biochemical indexes, coagulation function, D-dimer and maternal and infant prognosis were compared between the two groups. Results Group NSP had the attack was in an earlier pregnancy, and have more patients with severe edema, ascites and fundus changes compared with Control Group（P〈0.01）, and had the incidence and mortality of hypoproteinemia, 24 h urine protein quantitation, hypercoagulability, renal dysfunction and maternal and infant complications as well as the incidence and mortality of perinatal infants significantly higher than Control Group（P〈0.01）. Conclusion NSP often occurs early in gestation and has great harm to mother and infant. It is necessary to closely and dynamically monitor the situation of mother and children and improve the prognosis.

关 键 词：妊娠期高血压疾病 肾病综合征 母婴 并发症 

分 类 号：R714.24[医药卫生—妇产科学]