过敏性紫癜细胞因子基因多态性的研究进展  

Research progress of gene polymorphism of cytokines in Henoch-Schonlein purpura

作　　者：席乐迎 任献青[2] XI Leying;REN Xianqing(Henan University of Traditional Chinese Medicine,Zhengzhou 450000,Chin)

机构地区：[1]河南中医药大学 [2]河南中医药大学第一附属医院儿科

出　　处：《中国中西医结合儿科学》2018年第4期282-286,共5页Chinese Pediatrics of Integrated Traditional and Western Medicine

摘　　要：过敏性紫癜是儿童常见的小血管炎,近年来发病率逐年上升,目前其发病机制尚未完全明确。从基因水平上研究过敏性紫癜的发病机制成为研究领域的热点之一,已有相关研究显示某些细胞因子的基因多态性如白细胞介素基因、血管紧张素原基因、人类白细胞抗原基因、血管内皮生长因子等与过敏性紫癜的发病机制、病理进展及预后相关,本文通过对相关细胞因子多态性的文献进行查阅和综合分析,为今后从基因水平研究过敏性紫癜的发病机制等提供文献参考。Henoch-Schonlein purpura（HSP） is the common vasculitis affecting mainly children. In recent years, the incidence of HSP has been increasing while its pathogenesis is still unclear. Studying the pathogenesis of HSP from the gene level becomes one of the hotspots in the research field. Recently some studies have shown that the gene polymorphism of certain cytokines are related to the pathogenesis, pathological progression and prognosis of HSP, e.g., interleukin gene, angiotensinogen gene, human leukocyte antigen gene, and vascular endothelial growth factor gene, etc. Through the literature review and comprehensive analysis of the related cytokine polymorphisms, this paper provides references for future research on the pathogenesis of HSP from gene level.

关 键 词：过敏性紫癜 细胞因子 基因多态性 儿童 

分 类 号：R725.5[医药卫生—儿科]