乌司他丁联合比阿培南治疗老年重症肺炎的临床疗效观察  

Clinical Study on Ulinastatin Combined with Biapenem in Treatment of Elderly Patients with Severe Pneumonia

作　　者：蔡楠 蒋敏 何飞 CAI Nan, JIANG Min, HE Fei(Department of Emergency Medicine, Nanjing Drum Tower Hospital, Nanjing 210008, China)

机构地区：[1]南京鼓楼医院急诊医学科,南京210008

出　　处：《药学与临床研究》2018年第4期308-310,共3页Pharmaceutical and Clinical Research

摘　　要：观察乌司他丁联合比阿培南治疗老年重症肺炎的临床疗效,选取2013~2015年我院老年重症肺炎患者73例,随机分为对照组37例和试验组36例,对照组给予比阿培南0.3 g,加入0.9%氯化钠注射液100 mL q8h;试验组在对照组基础上加用乌司他丁注射液25万U,加入0.9%氯化钠注射液100 mL bid。两组患者均治疗2周。比较两组临床疗效,观察两组的C-反应蛋白(CRP)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、动脉血气指标。结果显示,对照组和试验组总有效率分别为51.3%、80.5%,两组比较差异有统计学意义(P<0.05)。治疗后,两组发热、肺部啰音及咳嗽等症状消失时间比较差异较大,有统计学意义(P<0.05)。试验组的CRP、PCT、TNF-α显著下降,动脉血气分析指标中血氧分压、二氧化碳分压、氧合指数均显著优于对照组(P<0.05)。由此认为,乌司他丁联合比阿培南在老年重症肺炎的治疗中有协同作用,联合应用可有效改善患者临床症状、降低机体炎症反应,提高疗效。In order to observe the clinical efficacy of ulinastatin combined with biapenem in the treatment of severe pneumonia in elderly patients,73 cases of elderly severe pneumonia in our hospital from2013 to 2015 were selected and randomly divided into control group（37 cases） and experimental group.Patients in the control group were given biapenem,0.3 g in normal saline 100 mL,q8 h;those in the test group were treated with ulinastatin,250,000 U in normal saline 100 mL,bid on the basis of the control group.Patients in both groups were treated for 2 weeks.Between the two groups,the levels of CRP,PCT and TNF-α,and the clinical curative effects were compared.The results showed that the total effective rates of the control group and the experimental group were 51.3% and 80.5%,respectively,the difference between the two groups was statistically significant（P〈0.05）.After treatment,the antipyretic time,the disappearance of pulmonary rales and coughing time in the experimental group were significantly shorter than those in the control group（P〈0.05）.The levels of CRP,PCT and TNF-α in the experimental group were significantly decreased.The arterial blood gas analysis results of partial pressure of oxygen,partial pressure of carbon dioxide and oxygenation index were significantly superior in the control group（P〈0.05）.It can be concluded that ulinastatin synergizes with biapenem in the treatment of elderly patients with severe pneumonia,the combination can effectively improve the clinical symptoms of patients,reduce the body＇s inflammatory response and improve efficacy.

关 键 词：注射用乌司他丁 注射用比阿培南 重症肺炎 老年人 

分 类 号：R969.4[医药卫生—药理学]