允许性高碳酸血症对丙泊酚复合舒芬太尼全凭静脉复合麻醉效果的影响  

Effects of permissive hypercapnia on Propofol combined with Sufentanil combined intravenous anesthesia

作　　者：黎秋焱 LI Qiu-yan(Department of Anesthesiology,Jiangxi Chest Hospital,Jiangxi Province,Nanchang 330006,China)

机构地区：[1]江西胸科医院麻醉科,江西南昌330006

出　　处：《中国当代医药》2018年第24期93-95,共3页China Modern Medicine

摘　　要：目的探讨允许性高碳酸血症对丙泊酚复合舒芬太尼全凭静脉复合麻醉效果的影响。方法选取2016年3月~2017年3月我院收治的90例择期拟行全身麻醉手术患者为研究对象,按入院时间顺序随机分为对照组和研究组,每组各45例。在麻醉期间,对照组控制动脉二氧化碳分压(Pa CO_2)在35~40 mm Hg,研究组则控制Pa CO_2在50~65 mm Hg。比较两组的丙泊酚应用情况(丙泊酚切皮时与腹腔探查效应部位浓度、术后苏醒时间)及术后1、2 h的Pa CO_2水平。结果 (1)研究组丙泊酚切皮时效应部位浓度为(2.511±0.206)mg/L,腹腔探查效应部位浓度(2.146±0.282)mg/L,均分别低于对照组(3.223±0.188)mg/L和(2.883±0.211)mg/L,差异有统计学意义(P<0.05)。对照组术后苏醒时间为(15.35±3.22)min,与研究组的(16.68±5.36)min比较,差异无统计学意义(P>0.05);(2)研究组术后1、2 h的Pa CO_2水平分别为(57.45±5.33)mm Hg、(59.39±5.66)mm Hg,均明显高于对照组的(35.24±4.32)mm Hg、(37.56±5.68)mm Hg,差异有统计学意义(P<0.05)。结论全身麻醉手术患者采用允许性高碳酸血症是安全可行的。Objective To investigate the effect of permissive hypercapnia on Propofol combined with Sufentanil combined intravenous anesthesia. Methods From March 2016 to March 2017, 90 cases of general anesthesia were selected in our hospital as study objects, and the patients were randomly divided into the control group（45 cases） and the study group（45 cases） according to the order of admission time. During the period of anesthesia, the arterial carbon dioxide partial pressure（PaCO2） of the control group was between 35-40 mm Hg, while the study group was Pa CO2 between 50-65 mm Hg. The application of Propofol in two groups was compared（the concentration of Propofol and abdominal exploration and the time of postoperative recovery） and the Pa CO2 level of 1, 2 h after operation. Results（1） In the study group, the concentration of the effector domain was（2.511±0.206） mg/L at skin incision, and the concentration of the effector domain was（2.146±0.282） mg/L at intraperitoneal exploration, were lower than those of the study group（3.223±0.188） mg/L and（2.883±0.211） mg/L respectively, and the difference was statistically significant（P〈0.05）. The recovery time in control group was（15.35±3.22） min, which was not significantly different from that in the study group（16.68＋5.36） min（P〉0.05）.（2）The Pa CO2 levels of 1, 2 h in the study group were（57.45±5.33） mm Hg and（59.39±5.66） mm Hg respectively, which were significantly higher than those in the control group（35.24±4.32） mm Hg and（37.56±5.68） mm Hg,and the difference was statistically significant（P〈0.05）. Conclusion It is safe and feasible to adopt permissive hypercapnia in patients undergoing general anesthesia.

关 键 词：允许性高碳酸血症 丙泊酚 舒芬太尼 静脉 麻醉 

分 类 号：R614[医药卫生—麻醉学]