血栓通治疗原位肝移植患者肝动脉血流及其阻力指数的变化  

Effect of Xueshuantong on hepatic arterial blood flow and resistance index in patients after orthotopic liver transplantation

作　　者：孙建军[1] 王维伟[1] 陈国勇[1] 魏思东[1] 汤高枫[1] 谢占涛[1] 陈建斌[1] 赵会博 Sun Jianjun;Wang Weiwei;Chen Guoyong(Department of Hepatobiliary and Pancreatic Surgery,Provincial People＇s HospitaI,Zhengzhou 400003,Henan Province,China)

机构地区：[1]河南省人民医院肝胆胰腺外科,郑州市400003

出　　处：《实用肝脏病杂志》2018年第5期769-772,共4页Journal of Practical Hepatology

摘　　要：目的探讨应用血栓通粉针治疗原位肝移植患者对肝动脉血流及其阻力指数的影响。方法良性终末期肝病接受肝移植患者40例,被分为治疗组和对照组各20例。术后给予治疗组血栓通静脉滴注,在对照组给予生理盐水治疗,治疗2 w。使用Acuson Sequoia 512彩色多普勒超声诊断仪采用连续、动态彩色多普勒血流显像测量左、右肝动脉血流和阻力指数。结果在术后1个月、6个月和18个月,血栓通组患者肝动脉血流分别为51.22±12.11 cm/s、61.32±11.87 cm/s和65.38±12.76 cm/s,明显快于对照组的47.18±14.25 cm/s、51.33±13.24cm/s和53.45±11.43 cm/s(P<0.05),肝动脉阻力指数分别为0.66±0.13、0.62±0.12和0.68±0.11,明显低于对照组的0.72±0.14、0.71±0.11和0.75±0.14,差异有统计学意义(P<0.05);术后血清胆红素和谷丙酶水平显著低于对照组(P<0.05)。结论血栓通能改善肝移植术后患者肝动脉血流,降低阻力指数,改善肝功能指标。Objective To investigate the effect of Xueshuantong,a herbal compound,on hepatic arterial blood flow and resistance index in patients after orthotopic liver transplantation（OLT）.Methods 40 patients with benign end-stage liver disease received OLT,and 20 was administered with Xueshuantong injection intravenously,and another 20 without after OLT.The hepatic artery blood flow and resistance index were measured by color Doppler sonography.Results The hepatic artery blood flow in patients receiving Xueshuantong at the end of 1 month,6 months and 18 months were 51.22 ±12.11 cm/s,61.32 ±11.87 cm/s and 65.38 ±12.76 cm/s,significantly higher than 47.181±4.25 cm/s,51.33±13.24 cm/s and 53.45±11.43 cm/s in the control（P〈0.05）,and the hepatic artery resistance index were 0.66±0.13,0.62±0.12 and 0.68±0.11,significantly lower than 0.72±0.14,0.71±0.11 and0.75 ±0.14 in the control（P〈 0.05）;serum bilirubin and ALT levels were significantly lower than those in the control group（P〈0.05）.Conclusion Application of Xueshuantong injection can improve the hepatic artery blood flow,decrease resistance index and improve the liver function in patients after OLT.

关 键 词：肝移植 血栓通 肝动脉血流 阻力指数 

分 类 号：R657.3[医药卫生—外科学]