奥美拉唑联合替普瑞酮预防早期胃癌内镜黏膜下剥离术后并发症65例临床观察  

Clinical Observation on Omeprazole Combined with Teproone in the Prevention of Complications After Endoscopic Submucosal Dissection for Early Gastric Cancer in 65 Cases

作　　者：王新钊[1] 马丽娟 申民强[1] Wang Xinzhao;Ma Lijuan;Shen Minqiang(Department of Gastroenterology,The 152nd Hospital of PLA,Pingdingshan,Henan,China 467000)

机构地区：[1]中国人民解放军第152医院消化内科,河南平顶山467000

出　　处：《中国药业》2018年第18期37-39,共3页China Pharmaceuticals

基　　金：北京医卫健康公益基金会医学科学研究基金资助项目[YWJKJJHKYJJ-A105]

摘　　要：目的观察奥美拉唑联合替普瑞酮预防早期胃癌内镜黏膜下剥离术(ESD)后并发症的疗效。方法选择2015年6月至2017年6月在医院接受ESD的早期胃癌患者130例,按随机数字表法分为观察组和对照组,各65例。ESD术后,对照组患者采用奥美拉唑治疗,观察组患者在此基础上联合替普瑞酮治疗,均治疗1周。结果两组患者术后第3,5天时腹痛评分显著降低(P<0.05),溃疡面积显著缩小(P<0.05),且观察组明显优于对照组(P<0.05);术后第7天,两组患者溃疡分期无显著性差异(P>0.05);术后第14天,两组患者溃疡分期差异显著(P<0.05),观察组患者溃疡愈合级别显著高于对照组(P<0.05);两组消化道出血发生率相当(1.54%比4.61%,P>0.05),药品不良反应发生率均为1.54%(P>0.05)。结论奥美拉唑联合替普瑞酮能减轻早期胃癌患者的腹痛症状,加快创面溃疡的修复,减少EDS术后并发症。Objective To observe the clinical effect of omeprazole combined with teprarone in the prevention of complications after endoscopic submucosal dissection（ESD） for early gastric cancer. Methods Totally 130 patients with early gastric cancer undergoing ESD in the hospital from June 2015 to June 2017 were divided into the observation group and the control group by the random number table method, 65 cases in each group. After ESD, the control group was treated with omeprazole, and the observation group was treated with esomeprazole combined with teprarone. The two groups were treated for 1 week. Results The scores of abdominal pain in the two groups were significantly decreased on the 3rd and 5th postoperative day（P 〈 0.05）,and the ulcer area in the two groups was reduced significantly（P 〈 0.05）, and those in the observation group were significantly better than those in the control group（P 〈 0.05）. There was no significant difference in the stage of ulcer between the two groups on the 7th postoperative day（P 〉 0.05）, while there was a significant difference in the stage of ulcer between the two groups on the 14th postoperative day（P 〈 0.05）.The ulcer healing level in the observation group was significantly higher than that in the control group（P 〈 0.05）. The incidence rate of gastrointestinal bleeding in the two groups was similar（1.54% vs. 4.61%, P 〉 0. 05）. Both of the incidence rate of adverse drug reactions in the two groups were 1.54% （P 〉 0.05）. Conclusion Omeprazole combined with tepritone can relieve symptoms of abdomi- nal pain,accelerate the ulcer wound healing and reduce complications after EDS in patients with early gastric cancer.

关 键 词：奥美拉唑 替普瑞酮 早期胃癌 内镜黏膜下剥离术 并发症 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R979.1[医药卫生—药学]