南通市学龄儿童双酚A暴露现状及其与肥胖的关系  

Status of bisphenol A exposure and its relationship with obesity in school-age children in Nantong city

作　　者：赵金华[1] 洪菲[1] 陆生丽[1] 周峰[2] 徐明[1] ZHAO Jin-hua;HONG Fei;LU Sheng-li;ZHOU Feng;XU Ming(Department of Paediatrics 1.Department of Laboratory;the First People ＂s Hospital of Nantong City,Nantong 226001,Jiangsu,CHINA)

机构地区：[1]南通市第一人民医院儿科,江苏南通226001 [2]南通市第一人民医院检验科,江苏南通226001

出　　处：《海南医学》2018年第16期2263-2265,共3页Hainan Medical Journal

基　　金：江苏省南通市卫生局基金项目(编号:YYZ16018)

摘　　要：目的探究南通市学龄儿童双酚A暴露现状及其与肥胖之间的关系。方法随机于2016年9月至2017年9月抽取600名小学(来自崇川区、港闸区、通州区)在校生,测量、评估儿童的体格状况,同时收集其尿液样本,开展双酚A浓度检测,分析男童与女童之间的双酚A差异,以及肥胖与双酚A暴露之间的关系。结果学龄儿童双酚A总检出率为76.00%,男童检出率为78.32%,女童检出率为73.89%,差异无统计学意义(P>0.05);肌酐校正前后女童的双酚A浓度[(1.20±0.31)ng/mL,(2.46±0.63)ng/mL]均明显高于男童[(0.93±0.27)ng/mL,(0.83±0.11)ng/mL],差异均具有统计学意义(P<0.05);600名学龄儿童中,有12.83%为肥胖、20.17%为超重、64.33%为正常、2.67%为消瘦,各组双酚A检出率分别为77.92%、74.38%、76.17%、75.00%,各组检出率之间比较差异无统计学意义(P>0.05);肥胖组与超重组的双酚A水平分别为(2.36±0.25)ng/mL、(2.05±0.36)ng/mL,明显高于正常组的(1.43±0.24)ng/mL和消瘦组的(1.26±0.31)ng/mL,差异均具有统计学意义(P<0.05)。结论双酚A暴露情况在学龄儿童中普遍存在,肥胖儿童尿中双酚A水平高于体重正常儿童,提示双酚A暴露可能是肥胖的危险因素之一。Objective To explore the current status of bisphenol A（BPA） exposure and its relationship with obesity in school-age children in Nantong city. Methods From September 2016 to September 2017, 600 students were randomly selected from primary schools in Chongchuan District, Gangza District and Tongzhou District to measure and evaluate the children＇s physical condition. Their urine samples were collected at the same time, and bisphenol A concentration was measured to analyze the differences of BPA between boys and girls, as well as the relationship between obesity and BPA exposure. Results The total positive rate of BPA in school-age children was 76.00%; the detection rate of boys was 78.32% compared to 73.89% of girls, P0.05. Before and after creatinine correction, the concentration of BPA in girls were（1.20±0.31） ng/mL,（2.46±0.63） ng/mL, were significantly higher than（0.93±0.27） ng/mL,（0.83±0.11） ng/mL） of boys（P0.05）. Among the 600 school-age children, 12.83% were obese, 20.17% were overweight, 64.33% were normal and 2.67% were wasting. The detection rates of BPA in each group were 77.92%, 74.38%, 76.17%, 75.00%, respectively, with no significant difference in the detection rate between the four groups（P0.05）. The level of BPA in obesity group（2.36±0.25） ng/mL and overweight group（2.05±0.36） ng/mL were significantly higher than that in the normal group（1.43±0.24） ng/mL and the wasting group（1.26±0.31） ng/mL, and the differences were statistically significant（P0.05）. Conclusion The exposure of bisphenol A is prevalent in school-age children. Obesity children have higher levels of BPA in urine than normal weight children, suggesting that exposure to BPA may be one of the risk factors for obesity.

关 键 词：南通 学龄儿童 双酚A 肥胖 

分 类 号：R179[医药卫生—妇幼卫生保健]