3D depth-coded photoacoustic microscopy with a large field of view for human skin imaging  被引量:5

3D depth-coded photoacoustic microscopy with a large field of view for human skin imaging

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作  者:Zhongwen Cheng Haigang Ma Zhiyang Wang Sihua Yang 程中文;马海钢;王志阳;杨思华(MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science,South China Normal University;College of Biophotonics,South China Normal University)

机构地区:[1]MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou 510631, China [2]College of Biophotonics, South China Normal University, Guangzhou 510631, China

出  处:《Chinese Optics Letters》2018年第8期58-61,共4页中国光学快报(英文版)

基  金:supported by the National Natural Science Foundation of China(Nos.11774101,61627827,81630046,and 91539127);the Science and Technology Planning Project of Guangdong Province,China(No.2015B020233016);the Distinguished Young Teacher Project in Higher Education of Guangdong,China(No.YQ2015049);the Science and Technology Youth Talent for Special Program of Guangdong,China(No.2015TQ01X882)

摘  要:Photoacoustic (PA) microscopy comes with high potential for human skin imaging, since it allows noninvasively high-resolution imaging of the natural hemoglobin at depths of several millimeters. Here, we developed a PA microscopy to achieve high-resolution, high-contrast, and large field of view imaging of skin. A three-dimensional (3D) depth-coding technology was used to encode the depth information in PA images, which is very intuitive for identifying the depth of blood vessels in a two-dimensional image, and the vascular structure can be analyzed at different depths. Imaging results demonstrate that the 3D depth-coded PA microscopy should be translated from the bench to the bedside.Photoacoustic (PA) microscopy comes with high potential for human skin imaging, since it allows noninvasively high-resolution imaging of the natural hemoglobin at depths of several millimeters. Here, we developed a PA microscopy to achieve high-resolution, high-contrast, and large field of view imaging of skin. A three-dimensional (3D) depth-coding technology was used to encode the depth information in PA images, which is very intuitive for identifying the depth of blood vessels in a two-dimensional image, and the vascular structure can be analyzed at different depths. Imaging results demonstrate that the 3D depth-coded PA microscopy should be translated from the bench to the bedside.

关 键 词:PA depth-coded photoacoustic microscopy with a large field of view for human skin imaging 

分 类 号:TH742[机械工程—光学工程]

 

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