早卵泡期长效长方案对多囊卵巢综合征患者体外受精临床结局的影响  

Impact of long protocol in early follicular phase of patients with polycystic ovary syndrome who undergone in vitro fertilization-embryo transfer on clinical outcomes

作　　者：赵志明[1] 郝桂敏[1] 崔娜[1] 曹金凤[1] 徐素欣[1] ZHAO Zhiming;HAO Guimin;CUI Na;CAO Jinfeng;XU Suxin(The Second Hospital of Hebei Medical University,Shijiazhuang,Hebei,05000)

机构地区：[1]河北医科大学第二医院生殖医学科,石家庄050000

出　　处：《中国计划生育学杂志》2018年第8期709-713,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨早卵泡期长效长方案对多囊卵巢综合征(PCOS)患者体外受精-胚胎移植(IVF-ET)结局的影响。方法:回顾性分析2016年1月-2017年12月于本院行首次IVF-ET的PCOS患者,采用卵泡期长效长方案226周期(卵泡组),同期采用黄体期长方案114周期(黄体组)及拮抗剂方案30周期(拮抗组)为对照,比较3组临床效果。结果:(1)卵泡组Gn使用天数、Gn使用量、hCG日子宫内膜厚度以及临床妊娠率、种植率明显高于黄体组(P<0.05),可利用胚数、可利用胚率明显低于黄体组(P<0.05);(2)卵泡组Gn使用天数、hCG日子宫内膜厚度、可利用胚数、可利用胚率均高于拮抗组(P<0.05),获卵数、临床妊娠率、种植率与拮抗组未见差异(P>0.05);OHSS发生率3组间未见差异(P>0.05)。结论:卵泡期长效长方案可能有助于提高子宫内膜容受性,从而改善PCOS患者临床结局。Objective：To explore the impact of long GnRH agonist protocol in early follicular phase on clinical outcomes of patients with polycystic ovary syndrome（PCOS）who undergone in vitro fertilization-embryo transfer（IVFET）.Methods：Retrospective analysis was performed on patients with PCOS who had undergone IVF-ET for the first time in the second hospital of Hebei medical university from January 2016 to December 2017.The protocol of long GnRH agonist in early follicle period（folicle group）was used in 226 cycles,which was compared with the protocol of long GnRH agonist in luteal phase（114 cycles,luteal phase group）or GnRH antagonist protocol（30 cycles,GnRH antagonist group）.The clinical outcomes of women in the three groups were compared.Results：Compared with those of women in luteal phase group,Gn used duration,total Gn dosage,endometrium thickness on HCG day,and the clinical pregnancy rate,and implantation rate of women in long protocol group were significant higher（P〈0.05）,but the available embryo number and available embryo rate were significant lower（P 0.05）.Compared with those of women in GnRH antagonist group,Gn used duration,endometrium thickness on HCG day,available embryo number,and available embryo rate of women in long protocol group were significant higher（P〈0.05）,but there were no significant difference in the number of retrieval oocytes,clinical pregnancy rate and implantation rate of women between long protocol group and GnRH antagonist group（P〉0.05）.The rate of OHSS among the three groups had no significant difference（P〉0.05）.Conclusion：The GnRH agonist long protocol in early follicular phase maybe help to improve endometrial receptivity,thereby can help to improve the clinical outcomes of patients with PCOS.

关 键 词：多囊卵巢综合征 体外受精 促性腺激素释放激素激动剂 长方案 临床结局 

分 类 号：R714.8[医药卫生—妇产科学]