超声波辐照比格犬左心室心肌运动同步性的在体实验研究  

Effects of different ultrasound power application on left ventricular myocardium synchrony in vivo open-chest Beagle canines

作　　者：李文华 尹立雪[1] 张红梅[1] 杨树[2] 陆景[1] 苗俊旺[3] 林薿[1] 黄宇 丁戈琦 邓燕[1] Li Wenhua;Yin Lixue;Zhang Hongmei;Yang Shu;Lu Jing;Miao Junwang;Lin Ni;Huang Yu;Ding Geqi;Deng Yan(Echocardiography ＆ Non-invasive Cardiology Laboratory,Ultrasound in Cardiac Electrophysiology and Biomechanics Key Laboratory of Sichuan Province,Sichuan Academy of Medial Sciences ＆ Sichuan Provincial People＇s Hospital,Chengdu 610072,China)

机构地区：[1]四川省医学科学院·四川省人民医院心血管超声及心功能科超声心脏电生理学与生物力学四川省重点实验室,成都610072 [2]四川省医学科学院·四川省人民医院神经内科,成都610072 [3]山西医学科学院·山西大医院超声科

出　　处：《中华超声影像学杂志》2018年第8期720-724,共5页Chinese Journal of Ultrasonography

基　　金：国家自然科学基金项目（81671852）;四川省科技厅项目（2016TD0017,2017TD0015）

摘　　要：目的探讨不同超声波声能辐照及微泡造影剂干预下开胸比格犬在体左心室心肌运动同步性的变化。方法12只健康比格犬开胸模型，随机分为A、B两组（每组各6只）。A组：诊断超声波声能约300mW，单纯诊断超声波辐照5min、注射微泡造影剂联合诊断超声波辐照5min和注射微泡造影剂后20min，分别采集左心室短轴二尖瓣水平、乳头肌水平、心尖水平各3个完整心动周期的实时灰阶二维图像；B组：超声波声能1W、2W、3W，分别辐照5min后采集相应以上图像。应用SyngoVVI工作站，分别获取左心室心内膜下心肌（subendo）和心外膜下心肌（subepi）整体径向位移达峰时间（RD-PT）和达峰时间标准差（RD-PTSD）。结果A组：与基础状态相比，三种干预状态下左心室心内膜、心外膜的RD-PT和RD-PTSD无明显变化，差异无统计学意义（均P〉0．05）；左心室心内膜与心外膜之间比较，相同状态下RD—PT、RD-PTSD无明显变化，差异无统计学意义（均P〉0．05）。B组：与基础状态相比，超声波声能1W、2W、3W辐照左心室心内膜、心外膜的RD-PT和RD-PTSD均呈增大趋势，2W辐照心内膜的RD-PT和RD-PTSD差异具有统计学意义（均P〈0．05），3W辐照心内膜、心外膜的RD-PT和RD—PTSD差异具有统计学意义（均P〈0．05）；左心室心内膜和心外膜之间比较，仅3W辐照RD-PT、RD-PTSD差异具有统计学意义（均P〈0．05）。结论诊断超声波辐照、微泡造影剂联合诊断超声波辐照5min、微泡造影剂后20min对左心室心肌运动同步性没有影响；超声波声能大于1W辐照可诱导左心室心内膜、心外膜的RD-PT和RD-PTSD延迟；超声波声能3W辐照可导致心肌运动失同步性。Objective To evaluate left ventricular （LV） myocardial mechanical synchrony with contrast agent and different power irradiation in open chest Beagle canines. Methods The anesthetized open-chest Beagle canines were assigned into two groups randomly： Group A （n = 6） for baseline, diagnostic ultrasound power irradiation （300 mW） 5 min, combined with contrast agent irradiation 5 rain and contrast agent 20 rain conditions;Group B （ n = 6） for baseline and intensity ultrasound irradiation （1 W, 2 W and 3 W, 5 min respectively） conditions. The standard short-axis gray-scale views at levels of mitral annulus （MV）, papillary muscle（PM）, and apex（AP） during 3 complete cardiac cycles in open chest Beagle canine models were acquired. The global radial displacement peak time （RD-PT） and standard deviation of peak time （RD-PTSD） of LV subendomyocardium （subendo） and subepimyocardium （subepi） were measured and analyzed by using a dedicated Syngo velocity vector imaging （VVI） method. Results In group A, compared with baseline condition, the RD-PT and RD-PTSD of subendo and subepi had no significant different among diagnostic power irradiation, contrast agent irradiation 5 min and contrast agent 20 min （all P 〈0.05）. There was no significant different in the RD-PT and RD-PTsD between subendo and subepi in A group in all conditions （all P 〈0.05）. In group B, the RDPT and RD-PTsD of subendo and subepi with power 1 W, 2 W and 3 W was higher than those with baseline condition; the RD-PT and RD- PTsD of subendo were significant different on 2 W compared with those on baseline condition （all P 〈 0. 05） ; the RD-PT and RD-PTSD of subendo, subepi were significant different on 3 W compared with baseline condition （all P 〈0.05）;the RD-PT and RD-PTSD were significant difference between subendo and subepi in only 3 W condition （all P 〈 0.05）. Conclusions Diagnostic ultrasound power irradiation 5 min and combined with contrast agent irradiation 5 min and contr

关 键 词：超声处理 心室功能 左 比格犬 同步性 

分 类 号：R445.1[医药卫生—影像医学与核医学] R541[医药卫生—诊断学]