阿尔茨海默病中β淀粉样蛋白作用机制的研究进展  

Progress in research on action mechanism of amuyloid protein-β in Alzheimer disease

作　　者：魏俊 赵范范 商迎辉[1] 劳凤学[1] WEI Jun;ZHAO Fan-fan;SHANG Ying-hui;LAO Feng-xue(Beijing Key Laboratory of Bioactive Substances and Functional Foods,College of Biochemistry and engineering of Beijing Union University,Beijing 100191,China)

机构地区：[1]北京联合大学生物化学与工程学院北京市生物活性物质和功能食品重点实验室,北京100191

出　　处：《中国生物制品学杂志》2018年第8期918-922,共5页Chinese Journal of Biologicals

基　　金：国家自然科学基金面上项目(31471587)

摘　　要：阿尔茨海默病(Alzheimer disease,AD)是一种常见的中枢神经系统退行性病变,老年人是高发人群,严重影响老年人的健康及生活质量。AD患者脑内形成神经炎性淀粉斑,即老年斑(senile plaque,SP)是其病理特征之一,SP主要由细胞外的β淀粉样蛋白(Amyloid-β,Aβ)沉积而成。Aβ是一个具有β片层的二级结构多肽,由淀粉样前体蛋白(APP)经水解产生后在脑内聚集,引发相应的神经毒性,造成神经元死亡,从而导致AD的发生和发展。Aβ在AD发病过程中起着重要作用,但其具体作用机制尚未明确。本文就近年来对Aβ的产生、分布与清除、传递与运输的研究进展作一综述。Alzheimer disease（AD）,the most common neurodegenerative disorder disease,is pathologically manifested by progressive cognitive dysfunction concomitant with the accumulation of senile plaques in the brain of affected individuals. Senile plaques（SP） are mainly composed of large extracellular aggregates of the amyloid β（Aβ） derived from the transmembrane region of the amyloid precursor protein（APP）. Several recent studies show that the exogenous injection with Aβ causes the accumulation of Aβ in brain,resulting in the neurotoxicity and the death of neuron. Aβplays an important role in the pathogenesis of Alzheimer disease,of which the exact mechanism is still unclear. This paper reviews the progress in research on production,distribution,removal,delivery and transport of Aβ.

关 键 词：阿尔茨海默病 Β淀粉样蛋白 分布 清除 传递 运输 

分 类 号：R592[医药卫生—老年医学]