以药测证法对大鼠寒凝血瘀证关键证素的研究  

Study on the key syndromes of cold-coagulation and blood Stasis syndrome treated by drug syndromes

作　　者：徐小荟 熊丽辉[1] XU Xiaohui;XIONG Lihui(Changchun University of Chinese Medicine,Changchun 130117,China)

机构地区：[1]长春中医药大学,长春130117

出　　处：《长春中医药大学学报》2018年第4期656-658,共3页Journal of Changchun University of Chinese Medicine

基　　金：吉林省中医药管理局课题"基于古籍整理的寒凝血瘀证最佳治则研究"(2016079)

摘　　要：目的以《中华医典》治疗寒凝血瘀证(实寒致瘀)的高频药物当归、香附、附子为切入点,探讨活血、行气、温阳单法及联合疗法对寒凝血瘀大鼠表征的影响,从而确定寒凝血瘀证的关键证素,以明确最佳治疗原则。方法采用全身冷冻法造模,将造模成功的大鼠,分别用附子、香附、当归单味药及联合组药物灌胃15 d,观察不同给药组大鼠表征及相应指标的变化。结果附子组对改善寒凝血瘀大鼠表征和TNF-α、IL-1β作用明显。结论治疗寒凝血瘀证以阳虚为主,应重用温阳,而活血、行气可少用。Objective To explore the effects of activating blood circulation, regulating qi, warming yang and combination therapy with Chinese Medical Code for treating high-frequency drugs such as Angelica sinensis, Cyperus rotundus and Radix Aconiti Lateralis, cold coagulation and blood stasis in rats, so as to determine the key elements of cold coagulation syndrome, in order to clarify the best treatment principle. Methods The model of systemic freezing method, the successful model rats, respectively, aconite, incense, Angelica single medicine and combination group of drugs for 15 days, to observe the changes of the rats in different administration groups and the corresponding indexes.Results The aconite group can improve the characterization of cold-bloody stasis and the most obvious of TNF-α and IL-1β. Conclusion treatment of cold coagulation syndrome with yang-based, should be reused yang and qi and blood can be used less.

关 键 词：附子 香附 单味药 大鼠 寒凝血瘀证 

分 类 号：R241.6[医药卫生—中医诊断学]