健康人群年龄与血管内皮功能、氧化应激水平的相关性分析  

Correlation analysis of age with endothelial function and oxidative stress in the healthy population

作　　者：潘洁[1] 刘安楠[1] 曹素艳[1] 王蕾蕾[1] Pan Jie;Liu Annan;Cao Suyan;Wang Leilei(VIP Department,Beijing Hospital,National Center of Gerontology,Beijing 100730,China)

机构地区：[1]北京医院特需医疗部国家老年医学中心,100730

出　　处：《中华现代护理杂志》2018年第21期2551-2553,共3页Chinese Journal of Modern Nursing

基　　金：北京医院院级科研课题资助项目（2016BJYYEC-042-01）

摘　　要：目的 评估健康人群血管内皮功能和氧化应激水平,为初步构建健康人群血管内皮功能异常的护理措施提供依据.方法 2016年3—10月采用方便抽样法选取北京医院体检中心查体人群296名.按年龄分为青年组（30-44岁）、中年组（45-59岁）及老年组（60-79岁）,所有入选者测定常规生化指标、血一氧化氮（NO）、血内皮素（ET-1）、血丙二醛（MDA）、血超氧化物歧化酶（SOD）,检测肱动脉血流介导的内皮依赖性血管舒张功能（FMEDD）.结果 不同年龄人群FMEDD、NO、SOD比较差异有统计学意义（P〈0.05）.进一步检验,老年组分别与青年组、中年组比较以及青年组与中年组之间比较,FMEDD、NO、SOD均差异有统计学意义（P〈0.05）.年龄与空腹FMEDD、NO、SOD呈负相关（r值分别为-0.7678、-0.4652、-0.6250;P〈0.05）;年龄与ET-1、MDA呈正相关（r值分别为0.1126、0.0957;P〈0.05）.结论 健康人群血管内皮功能和抗氧化应激指标随年龄增长而下降,尤其要关注60岁以上老年人血管内皮功能的下降;对于既往无高血压病、糖尿病、高脂血症等疾病的老年人群,我们应严格控制好血压、血糖、血脂等影响血管内皮功能的代谢指标,早期预防血管内皮功能的下降.Objective To evaluate the vascular endothelial function and oxidative stress level in the healthy population, and to provide evidence for preliminary nursing care regarding abnormal endothelial function in healthy people. Methods A total of 296 healthy people who had physical examination in Beijing Hospital from March to October 2016 were selected in this study using convenience sampling. The participants were divided into the youth group （30-44 years old）, middle-aged group （45-59 years old） and elderly group （60-79 years old）. The routine biochemical indexes, blood nitric oxide （NO）, blood endothelin （ET-1）, blood malondialdehyde （MDA）, blood superoxide dismutase （SOD）, and brachial artery flow mediated endothelium dependent vasodilatation function （FMEDD） were measured for the participants. Results There were significant differences in FMEDD, NO and SOD among different age groups （P 〈 0.05）. The age was negatively correlated with fasting FMEDD, NO and SOD （r=-0.767 8, -0.465 2, -0.625 0; P 〈 0.05）. However, a positive correlation was found between age and ET-1 and MDA （r= 0.112 6, 0.095 7; P 〈 0.05）. Conclusions The vascular endothelial function and antioxidant stress index decrease with age in the healthy population. The decline of vascular endothelial function in the elderly over 60 years old should be concerned. The elderly people should strictly control their blood pressure, blood ghmose, blood lipid and other risk factors for vascular endothelial function to prevent endothelial dysfunction in the early stage, especially in people who have no history of hypertension, diabetes, or hyperlipidemia.

关 键 词：年龄组 血管内皮功能 氧化应激 

分 类 号：R473[医药卫生—护理学]