不同子宫内膜准备方案的冻融胚胎移植临床结局比较  

Comparison of the effect of different endometrial preparation methods on the clinical outcome of frozen-thawed embryo transfer

作　　者：乔岩岩[1,2] 张俊博[2] 侯高林 牛冉冉 刘思佳[2] 孙秀芹[2] QIAO Yan-yan;ZHANG Jun-bo;HOU Gao-lin;NIU Ran-ran;LIU Si-jia;SUN Xiu-qin(School of Clinical Medicine of Jining Medical University,Jining,272100;Reproductive Medical Center of Jining No.1 People＇ s Hospital,Jining,272100)

机构地区：[1]济宁医学院临床学院,山东济宁272100 [2]济宁市第一人民医院生殖医学科,山东济宁272100

出　　处：《中国优生与遗传杂志》2018年第8期118-120,共3页Chinese Journal of Birth Health & Heredity

基　　金：济宁医学院青年基金项目(项目号:N o.JYQ2011KM044)

摘　　要：目的探讨不同子宫内膜准备方案对冻融胚胎移植(frozen-thawed embryo transfer,FET)临床治疗结局的影响。方法回顾性分析了济宁市第一人民医院生殖医学科2014年4月至2017年12月冻融胚胎移植共864周期,其中自然周期冻融胚胎移植494周期,微刺激周期冻融胚胎移植132周期,人工周期冻融胚胎移植217周期,降调节+人工周期冻融胚胎移植21周期。比较各组患者年龄、不孕年限、移植日内膜厚度、平均移植胚胎数、临床妊娠率、胚胎种植率、早期自然流产率及异位妊娠率。结果自然周期、微刺激周期、人工周期、降调节+人工周期四组患者的临床妊娠率分别为49.39%、48.48%、47.00%、52.38%,胚胎种植率分别为33.94%、35.12%、32.13%、41.02%,早期流产率分别为12.29%、3.13%、8.82%、9.09%,异位妊娠率分别为2.86%、6.25%、1.96%、0%,四组相比较,差异均无统计学意义(P>0.05)。结论四种子宫内膜准备方案在冻融胚胎移植周期可获得相似的临床效果。Objective：To compare the effect of different endometrial preparation methods on the clinical outcome of frozenthawed embryo transfer（FET）. Methods：Total 864 FET cycles from April 2014 to December 2017 were retrospectively analyzed and divided into four groups：natural cycle group（n=494）,ovulation induction cycle group（n=132）,artificial menstrual cycle group（n=217）,and gonadotropin-releasing hormone agonist（Gn RHa）suppression cycle group（n=21）. The patient age,duration of infertility,endometrial thickness,number of embryo transferred,and the rates of clinical pregnancy,embryo implantation,early abortion,and ectopic pregnancy between these four groups. Results：FET cycle outcomes were similar between these four groups. The clinical pregnancy rates of four groups were 49.39%,48.48%,47.00% and 52.38%. The rates of embryo implantation were 33.94%,35.12%,32.13% and 41.02%. The rates of early abortion were 12.29%,3.13%,8.82% and 9.09%. The rates of ectopic pregnancy were 2.86%,6.25%,1.96% and 0% respectively. There were no significant differences among them（P〉0.05）. Conclusion：Four endometrial preparation methods can have similar clinical outcome.

关 键 词：冻融胚胎移植 胚胎种植率 临床妊娠率 流产率 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]